Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid
Gagliardi G, Rodriguez-Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid. Communications Medicine 2023, 3: 106. PMID: 37528163, PMCID: PMC10394044, DOI: 10.1038/s43856-023-00324-7.Peer-Reviewed Original ResearchLogical Memory delayed recallEpisodic memory declineMemory declineCortical mean diffusivityAmyloid-positive participantsEntorhinal cortexAmyloid statusCognitively normal older adultsHarvard Aging Brain StudyInferior temporal lobeNormal older adultsOlder adultsAging Brain StudyCognitively normal participantsTau accumulationCognitively normal individualsBrain microstructural changesInteraction effectsTau PET imagingDelayed recallBaseline amyloid statusTemporal lobeEntorhinal tauNormal participantsBrain studies