Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia
DuBois J, Mathotaarachchi S, Rousset O, Sziklas V, Sepulcre J, Guiot M, Hall J, Massarweh G, Soucy J, Rosa-Neto P, Kobayashi E. Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia. NeuroImage Clinical 2020, 29: 102552. PMID: 33401137, PMCID: PMC7787952, DOI: 10.1016/j.nicl.2020.102552.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia patientsFocal cortical dysplasiaHealthy controlsCortical dysplasiaFCD patientsMetabotropic glutamate receptor type 5Contralateral hemisphereEpileptic activityPersistent epileptic activityDuration of epilepsySmall-world connectivityHigh centrality nodesMGluR5 availabilityIn vivo evidenceEpilepsy durationPatientsType 5Assess group differencesNetwork integrationMGluR5Binding potentialDysplasiaNetwork abnormalitiesGraph theoretical analysisEpilepsy