2017
Functional network integrity presages cognitive decline in preclinical Alzheimer disease
Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, Sepulcre J, Smith E, Rentz D, Johnson K, Sperling R, Chhatwal J. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology 2017, 89: 29-37. PMID: 28592457, PMCID: PMC5496516, DOI: 10.1212/wnl.0000000000004059.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer Cognitive CompositePreclinical Alzheimer Cognitive Composite scoreClinically normal older adultsNormal older adultsPreclinical Alzheimer's diseaseRs-fcMRICognitive declineBaseline connectivityResting-state functional connectivity MRIControl networkAD-related cognitive declineMeasures of network integrationFunctional connectivity MRIAlzheimer's diseaseNeuropsychological follow-upControl network connectivityOlder adultsFunctional network integrationCompound B PETPittsburgh compound B PETPredictor of ratingsNetwork integrationDorsal attentionCognitive compositeYears of follow-up
2013
Intrinsic Architecture Underlying the Relations among the Default, Dorsal Attention, and Frontoparietal Control Networks of the Human Brain
Spreng R, Sepulcre J, Turner G, Stevens W, Schacter D. Intrinsic Architecture Underlying the Relations among the Default, Dorsal Attention, and Frontoparietal Control Networks of the Human Brain. Journal Of Cognitive Neuroscience 2013, 25: 74-86. PMID: 22905821, PMCID: PMC3816715, DOI: 10.1162/jocn_a_00281.Peer-Reviewed Original ResearchConceptsFrontoparietal control networkDorsal attention networkControl networkResting-state functional connectivity MRIAttention networkGoal-directed cognitionExternally directed cognitionIntrinsic functional connectivityIntrinsic functional architectureFunctional connectivity MRITask-based activitiesDorsal attentionBrain networksBrain regionsFunctional connectivityHuman cognitionCognitionInternetwork communicationTask domainFunctional architecturePartial correlationPositive connectionBootstrap resampling procedureLarge-scale networksBrain