2023
Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increases
2021
Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
Kim C, Montal V, Diez I, Orwig W, Initiative A, Sepulcre J. Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging. Human Brain Mapping 2021, 42: 2990-3004. PMID: 33955621, PMCID: PMC8193537, DOI: 10.1002/hbm.25350.Peer-Reviewed Original ResearchConceptsCognitively normal older adultsAmyloid-betaPathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseTau depositionPositron emission tomographyGeneral cognitive impairmentTau neurofibrillary tanglesAlzheimer's diseaseNormal older adultsOlder adultsAmyloid-beta depositionCognitive test scoresTau pathogenesisAD vulnerable areasNeurofibrillary tanglesHeteromodal areasTau accumulationCognitive changesCognitive deteriorationCognitive impairmentCognitive declinePathological hallmarkPreclinical ADCognitive level
2019
Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease
Hanseeuw B, Betensky R, Jacobs H, Schultz A, Sepulcre J, Becker J, Cosio D, Farrell M, Quiroz Y, Mormino E, Buckley R, Papp K, Amariglio R, Dewachter I, Ivanoiu A, Huijbers W, Hedden T, Marshall G, Chhatwal J, Rentz D, Sperling R, Johnson K. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease. JAMA Neurology 2019, 76: 915-924. PMID: 31157827, PMCID: PMC6547132, DOI: 10.1001/jamaneurol.2019.1424.Peer-Reviewed Original ResearchMild cognitive impairmentOlder adultsChoice of outcome measuresPreclinical Alzheimer Cognitive CompositeCognitive impairmentAssociated with cognitive changesProspective cohort studyClinically normal participantsCognitive changesAssociated with subsequent changesMeasure cognitive changeHarvard Aging Brain StudyMeasured 7 yearsPreclinical Alzheimer's diseaseAging Brain StudyPittsburgh compound B PETAlzheimer's diseaseNormal older adultsPrevention trialsOutcome measuresSerial mediation modelCohort studyInclusion criteriaCompound B PETCognitive composite