2017
Fluorodeoxyglucose metabolism associated with tau‐amyloid interaction predicts memory decline
Hanseeuw B, Betensky R, Schultz A, Papp K, Mormino E, Sepulcre J, Bark J, Cosio D, LaPoint M, Chhatwal J, Rentz D, Sperling R, Johnson K. Fluorodeoxyglucose metabolism associated with tau‐amyloid interaction predicts memory decline. Annals Of Neurology 2017, 81: 583-596. PMID: 28253546, PMCID: PMC5404378, DOI: 10.1002/ana.24910.Peer-Reviewed Original ResearchConceptsMemory declineFrontal hypometabolismHarvard Aging Brain StudyAssociated with frontal hypometabolismCourse of preclinical ADAssociated with memory lossAging Brain StudySignificant memory declinePreclinical Alzheimer's diseaseCerebral glucose metabolismAlzheimer's diseaseCingulate metabolismPosterior cingulate metabolismEntorhinal tauEntorhinal cortexPositron emission tomographyPittsburgh compound BPreclinical ADBrain studiesMemory lossImpact of amyloidOlder adultsHypometabolismAge-related tauopathyEmission tomography
2011
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden
Drzezga A, Becker J, Van Dijk K, Sreenivasan A, Talukdar T, Sullivan C, Schultz A, Sepulcre J, Putcha D, Greve D, Johnson K, Sperling R. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain 2011, 134: 1635-1646. PMID: 21490054, PMCID: PMC3102239, DOI: 10.1093/brain/awr066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloidAniline CompoundsBenzothiazolesBrain MappingCerebral CortexCognition DisordersFemaleFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenPositron-Emission TomographyStatistics as TopicThiazolesConceptsWhole-brain connectivityDisruption of functional connectivityCortical hubsEarly functional consequencesMild cognitive impairmentFunctional connectivityAmyloid burdenCognitive impairmentNon-demented older individualsVoxel-based morphometry measuresAmyloid-positive patientsStructural magnetic resonanceDisruption of connectivityEmission tomographyCerebral glucose metabolismAlzheimer-type neurodegenerationAssociated with neuronal dysfunctionClinical Alzheimer's diseaseNon-demented subjectsCognitive symptomsIncreased amyloid burdenBrain regionsFunctional disconnectionNeuronal dysfunctionWhole-brain