Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder
Beucke J, Sepulcre J, Talukdar T, Linnman C, Zschenderlein K, Endrass T, Kaufmann C, Kathmann N. Abnormally High Degree Connectivity of the Orbitofrontal Cortex in Obsessive-Compulsive Disorder. JAMA Psychiatry 2013, 70: 619-629. PMID: 23740050, DOI: 10.1001/jamapsychiatry.2013.173.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeurobiological models of obsessive-compulsive disorderModels of obsessive-compulsive disorderOrbitofrontal cortexUnmedicated patientsAntidepressant medicationBasal gangliaSymptom severityObsessive-compulsive disorder symptom severityConsistent with neurobiological modelsTreated with antidepressant medicationResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingOCD symptom severityReduced local connectivityLocal functional connectivityBrain network propertiesDegree connectivityStatistical parametric mappingVentral striatumCase-control cross-sectional studyCorticostriatal circuitryNeurobiological modelsBrain circuitsConnectivity alterations