2021
Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities
Leaston J, Ferris C, Kulkarni P, Chandramohan D, van de Ven A, Qiao J, Timms L, Sepulcre J, Fakhri G, Ma C, Normandin M, Gharagouzloo C. Neurovascular imaging with QUTE-CE MRI in APOE4 rats reveals early vascular abnormalities. PLOS ONE 2021, 16: e0256749. PMID: 34449808, PMCID: PMC8396782, DOI: 10.1371/journal.pone.0256749.Peer-Reviewed Original ResearchConceptsVascular abnormalitiesAPOE-e4Contrast-enhanced magnetic resonance imagingBlood-brain-barrier leakageNeurovascular dysfunctionSmall vessel abnormalitiesMagnetic resonance imagingTri-synaptic circuitBlood-brain-barrierCross-sectional studyFemale ratsSignificant signal increaseHyper-vascularizationCerebrovascular abnormalitiesVessel abnormalitiesNeurovascular imagingQUTE-CEBrain volumeAnimal modelsPathological causesAbnormalitiesHistological validationImaging modalitiesResonance imaging
2020
Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade
Labayru G, Jimenez‐Marin A, Fernández E, Villanua J, Zulaica M, Cortes J, Díez I, Sepulcre J, de Munain A, Sistiaga A. Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade. Annals Of Clinical And Translational Neurology 2020, 7: 1802-1815. PMID: 32881379, PMCID: PMC7545612, DOI: 10.1002/acn3.51163.Peer-Reviewed Original ResearchConceptsVoxel Based MorphometryHealthy controlsFronto-subcortical networksPatterns of brain atrophyMultimodal integration networkExecutive function testsBrain structural abnormalitiesRegional brain volumesGM damageDM1 patientsNeuropsychological testsNeurodevelopmental originBrain changesPediatric onset patientsGM lossFrontal regionsVBM analysisWM volumeBrain abnormalitiesBrain volumeCognitive outcomesFollow-up MRI studiesHC groupYoung adulthoodImpairment assessment