2022
Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease
Basaia S, Agosta F, Diez I, Bueichekú E, Uquillas F, Delgado-Alvarado M, Caballero-Gaudes C, Rodriguez-Oroz M, Stojkovic T, Kostic V, Filippi M, Sepulcre J. Neurogenetic traits outline vulnerability to cortical disruption in Parkinson’s disease. NeuroImage Clinical 2022, 33: 102941. PMID: 35091253, PMCID: PMC8800137, DOI: 10.1016/j.nicl.2022.102941.Peer-Reviewed Original ResearchConceptsParkinson's diseaseBrain circuitsGene expression patternsBrain connectivityPD-related pathologyPD participantsHuman brainHuman cortexTopological intersectionConnectivity networksCortical propagation patternsPostmortem dataGenetic traitsBrainExpression patternsSNCA geneConnectivity trajectoriesGenesCellular componentsNeuronal damageNeuronal vulnerabilityVulnerabilityParkinsonTraits
2021
College education as a modulator of the aging brain
Sepulcre J. College education as a modulator of the aging brain. Nature Aging 2021, 1: 980-981. PMID: 37118340, DOI: 10.1038/s43587-021-00131-6.Peer-Reviewed Original ResearchCortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Frontiers In Human Neuroscience 2021, 15: 694274. PMID: 34381343, PMCID: PMC8350487, DOI: 10.3389/fnhum.2021.694274.Peer-Reviewed Original ResearchSynaptic plasticityOrganization of brain networksFunctional neuroimaging dataHuman brainCreative abilitiesBrain networksFunctional connectivityNeuroimaging phenotypesGraph theory approachNeuroimaging dataNeural plasticityCortical networksBiological basisCortical distributionConnectivity mapsDistributed connectivityCreative thinkingDistribution of genesGene expression distributionSets of genesGene expression informationBrainSynaptic assemblyGene expression profilesNeuroimagingConnectivity adaptations in dopaminergic systems define the brain maturity of investors
Ortiz-Teran E, Diez I, Sepulcre J, Lopez-Pascual J, Ortiz T. Connectivity adaptations in dopaminergic systems define the brain maturity of investors. Scientific Reports 2021, 11: 11671. PMID: 34083626, PMCID: PMC8175592, DOI: 10.1038/s41598-021-91227-x.Peer-Reviewed Original ResearchConceptsSenior investorsGray matter volumeDopamine-related pathwaysInvestment decisionsStructural brain connectivityBodily stress responsesFinancial tradingReward processingDopaminergic systemInvestorsMatter volumeBrain connectivityBrain maturationAssociated with adrenalineBodily awarenessBrain anatomyWork experienceHuman brainInvestmentBrainNoradrenaline biosynthesisStress responseConnectivity adaptation
2019
Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology Of Aging 2019, 88: 51-60. PMID: 31941578, PMCID: PMC7085436, DOI: 10.1016/j.neurobiolaging.2019.12.005.Peer-Reviewed Original ResearchConceptsAssociated with lower global cognitionCognitive impairmentAlzheimer's diseaseBrain network dysfunctionAD-related changesMild cognitive impairmentFrontoparietal networkSalience networkMode networkStrength of connectionsNetwork-based investigationsGlobal cognitionNetwork dysfunctionAD-related conditionsBrain connectivityConnectivity changesCortical regionsConnection distanceInvestigation of brain connectivityAD spectrumVoxel levelHealthy controlsDistance of connectionBrainPathways of connectivity
2018
Visual search task immediate training effects on task-related functional connectivity
Bueichekú E, Ávila C, Miró-Padilla A, Sepulcre J. Visual search task immediate training effects on task-related functional connectivity. Brain Imaging And Behavior 2018, 13: 1566-1579. PMID: 30443892, DOI: 10.1007/s11682-018-9993-y.Peer-Reviewed Original ResearchConceptsVisual search taskSearch taskTask-related functional connectivityCognitive control areasBrain-behavior correlationsDorsolateral prefrontal cortexBrain connectivity changesVisual search processImmediate training effectsTraining effectPrefrontal cortexConnectivity findingsPriming effectBrain changesBrain activityFunctional connectivityAssociation cortexBrain plasticityConnectivity changesCortical areasHuman brainHigher-order changesBrainTraining participantsEnhanced connectivity
2017
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association
2016
Epicenters of dynamic connectivity in the adaptation of the ventral visual system
Prčkovska V, Huijbers W, Schultz A, Ortiz‐Teran L, Peña‐Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping 2016, 38: 1965-1976. PMID: 28029725, PMCID: PMC5342908, DOI: 10.1002/hbm.23497.Peer-Reviewed Original ResearchConceptsFunctional connectivityReorganization of functional connectivityVentral visual systemDynamic functional connectivityCognitive processing areasRepetition paradigmBrain systemsRepetition-suppressionAssociation cortexSynchrony changesConnectivity changesGraph theory methodsPrimary visual areaSensory stimuliConnectivity reorganizationVisual areasNeuronal responsesProcessing areasCortexDistant connectionsEnhanced synchronyBrainAdvanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease
Sepulcre J, Masdeu J. Advanced Neuroimaging Methods Towards Characterization of Early Stages of Alzheimer’s Disease. Methods In Molecular Biology 2016, 1303: 509-519. PMID: 26235088, DOI: 10.1007/978-1-4939-2627-5_31.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional magnetic resonance imagingAlzheimer's diseaseEarly stages of Alzheimer's diseaseOxygen level-dependentMagnetic resonance imagingStages of Alzheimer's diseaseNeurobiological changesStructural neuroimagingBrain networksBrain regionsBrains of patientsPostmortem studiesLevel-dependentNeurobiology of ADFunctional networksPostmortem dataBrainQuiet wakefulnessTau depositionResonance imagingTherapeutic interventionsNetwork propertiesNeurobiologyNeuroimaging
2015
Hubs and Pathways
Sepulcre J, Sabuncu M, Goñi J. Hubs and Pathways. 2015, 441-447. DOI: 10.1016/b978-0-12-397025-1.00023-3.Peer-Reviewed Original Research
2014
Functional Streams and Cortical Integration in the Human Brain
Sepulcre J. Functional Streams and Cortical Integration in the Human Brain. The Neuroscientist 2014, 20: 499-508. PMID: 24737695, DOI: 10.1177/1073858414531657.Peer-Reviewed Original ResearchConceptsProcessing of brain informationHuman brainBrain functional connectomeFunctional streamsBrain systemsCortical hubsFunctional connectomeHuman cognitionOrganization of neuronal networksSensory cortexCortex areaCortical integrationBrainMotor cortex areaNeuronal interactionsNeuronal networksBrain informationCognitionCortexConnectomeIntegration of visual and motor functional streams in the human brain
Sepulcre J. Integration of visual and motor functional streams in the human brain. Neuroscience Letters 2014, 567: 68-73. PMID: 24699175, DOI: 10.1016/j.neulet.2014.03.050.Peer-Reviewed Original ResearchConceptsBlood oxygen level-dependentFunctional connectivity structureMultimodal integration networkHuman functional connectomeHuman brainBrain imaging methodsSynchronous brain activityOxygen level-dependentBrain regionsBrain activityFunctional streamsFunctional connectomeCerebral areasLevel-dependentInformation processingBrain researchBrainConnection structureCoupling patternsCoupling
2013
An OP4 Functional Stream in the Language-Related Neuroarchitecture
Sepulcre J. An OP4 Functional Stream in the Language-Related Neuroarchitecture. Cerebral Cortex 2013, 25: 658-666. PMID: 24084124, DOI: 10.1093/cercor/bht256.Peer-Reviewed Original ResearchConceptsBroca's areaAuditory-motorLanguage-related cortexAuditory-motor integrationFunctional neuroarchitectureMotor productionAuditory inputBrocaHuman speechWernickeSustainability languageFunctional network analysisFunctional streamsMotor outputLanguage symbolsMotorCortexNeuroanatomyOperculumParietaleComprehensionBrainSpeechNeuroarchitectureLanguageIndividual Variability in Functional Connectivity Architecture of the Human Brain
Mueller S, Wang D, Fox M, Yeo B, Sepulcre J, Sabuncu M, Shafee R, Lu J, Liu H. Individual Variability in Functional Connectivity Architecture of the Human Brain. Neuron 2013, 77: 586-595. PMID: 23395382, PMCID: PMC3746075, DOI: 10.1016/j.neuron.2012.12.028.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnimalsBrain MappingCerebral CortexFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedIndividualityMacaca mulattaMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedNeural PathwaysOxygenPhotic StimulationPredictive Value of TestsRegression AnalysisTime FactorsConceptsResting-state functional MRIHeteromodal association cortexFunctional connectivity architectureCognitive domainsUnimodal cortexIndividual differencesFunctional MRIFunctional connectivityAssociation cortexConnection variablesLong-range connectivityBrain anatomyCortical thicknessBrain evolutionHuman brainCortexSulcal depthIntersubject variabilityStatistical mapsIndividual variabilityConnectivity architectureBrainFunctional variablesLocal connectivityCortical expansionIntrinsic Architecture Underlying the Relations among the Default, Dorsal Attention, and Frontoparietal Control Networks of the Human Brain
Spreng R, Sepulcre J, Turner G, Stevens W, Schacter D. Intrinsic Architecture Underlying the Relations among the Default, Dorsal Attention, and Frontoparietal Control Networks of the Human Brain. Journal Of Cognitive Neuroscience 2013, 25: 74-86. PMID: 22905821, PMCID: PMC3816715, DOI: 10.1162/jocn_a_00281.Peer-Reviewed Original ResearchConceptsFrontoparietal control networkDorsal attention networkControl networkResting-state functional connectivity MRIAttention networkGoal-directed cognitionExternally directed cognitionIntrinsic functional connectivityIntrinsic functional architectureFunctional connectivity MRITask-based activitiesDorsal attentionBrain networksBrain regionsFunctional connectivityHuman cognitionCognitionInternetwork communicationTask domainFunctional architecturePartial correlationPositive connectionBootstrap resampling procedureLarge-scale networksBrain
2012
Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain
Sepulcre J, Sabuncu M, Yeo T, Liu H, Johnson K. Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain. Journal Of Neuroscience 2012, 32: 10649-10661. PMID: 22855814, PMCID: PMC3483645, DOI: 10.1523/jneurosci.0759-12.2012.Peer-Reviewed Original ResearchConceptsHigher-order brain systemsMultimodal integration networkOrganization of brain regionsHuman brainCognitive processing systemsPosterior parietal cortexBrain systemsNeuroimaging researchParietal cortexBrain regionsInternal cognitionPerceptual integrationFunctional connectomeModality-relatedMultimodal organizationPerceptual convergenceMultimodal integrationCortexBrainMultimode processesCognitionCoherence experimentsConnectomeConnective axisProcessing systemNetwork assemblies in the functional brain
Sepulcre J, Sabuncu M, Johnson K. Network assemblies in the functional brain. Current Opinion In Neurology 2012, 25: 384-391. PMID: 22766721, PMCID: PMC3471530, DOI: 10.1097/wco.0b013e328355a8e8.Peer-Reviewed Original Research
2010
The Organization of Local and Distant Functional Connectivity in the Human Brain
Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo B, Buckner R. The Organization of Local and Distant Functional Connectivity in the Human Brain. PLOS Computational Biology 2010, 6: e1000808. PMID: 20548945, PMCID: PMC2883589, DOI: 10.1371/journal.pcbi.1000808.Peer-Reviewed Original ResearchConceptsFunctional connectivityDistant functional connectivityIntrinsic functional connectivityAtypical brain functionHuman brainCortical-cortical interactionsInformation-processing efficiencyHeteromodal association areasObserved propertiesLong path lengthBrain systemsBrain regionsProcessing demandsTask performanceBrain functionAssociation areasSensorimotor cortexFunctional couplingModule couplingInformation processingBrainPath lengthCouplingLocal connectivityNetwork measuresFunctional-Anatomic Fractionation of the Brain's Default Network
Andrews-Hanna J, Reidler J, Sepulcre J, Poulin R, Buckner R. Functional-Anatomic Fractionation of the Brain's Default Network. Neuron 2010, 65: 550-562. PMID: 20188659, PMCID: PMC2848443, DOI: 10.1016/j.neuron.2010.02.005.Peer-Reviewed Original ResearchConceptsMedial temporal lobe subsystemNetwork of brain regionsBrain's default networkHuman functional imagingPersonally significant eventsDefault networkMidline coreSelf-relevanceMental sceneSpontaneous cognitionBrain regionsFunctional imagingSpontaneous actsSignificant eventsCognitionIntrinsic activityMemoryDecision makingBrainHypothesis
2009
Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors
Liu H, Stufflebeam S, Sepulcre J, Hedden T, Buckner R. Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 20499-20503. PMID: 19918055, PMCID: PMC2777963, DOI: 10.1073/pnas.0908073106.Peer-Reviewed Original ResearchConceptsBrain systemsBrain asymmetryCerebral lateralizationHuman brainLateral brain regionsIntrinsic activity fluctuationsLeft-handed individualsBrain regionsGroup differencesFactor analysisInternational thoughtEnvironmental mechanismsBrainIntrinsic activityActivity fluctuationsHand dominanceLateralizationThoughtsMeasured asymmetryEvidenceAdultsAsymmetryLanguageIndividualsFindings