2021
Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Frontiers In Human Neuroscience 2021, 15: 694274. PMID: 34381343, PMCID: PMC8350487, DOI: 10.3389/fnhum.2021.694274.Peer-Reviewed Original ResearchSynaptic plasticityOrganization of brain networksFunctional neuroimaging dataHuman brainCreative abilitiesBrain networksFunctional connectivityNeuroimaging phenotypesGraph theory approachNeuroimaging dataNeural plasticityCortical networksBiological basisCortical distributionConnectivity mapsDistributed connectivityCreative thinkingDistribution of genesGene expression distributionSets of genesGene expression informationBrainSynaptic assemblyGene expression profilesNeuroimaging
2020
Central neurogenetic signatures of the visuomotor integration system
Bueichekú E, Aznárez-Sanado M, Diez I, Uquillas F, Ortiz-Terán L, Qureshi A, Suñol M, Basaia S, Ortiz-Terán E, Pastor M, Sepulcre J. Central neurogenetic signatures of the visuomotor integration system. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 6836-6843. PMID: 32144139, PMCID: PMC7104395, DOI: 10.1073/pnas.1912429117.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutism Spectrum DisorderBrain MappingCalcium ChannelsCohort StudiesEpilepsies, MyoclonicFemaleHumansMaleMiddle AgedMotor CortexNAV1.1 Voltage-Gated Sodium ChannelNeurodevelopmental DisordersPrader-Willi SyndromeProteinsPsychomotor PerformanceT-Box Domain ProteinsVisual CortexVisual PerceptionConceptsAutism spectrum disorderVisuomotor integrationNeurogenetic syndromesAllen Human Brain AtlasHuman cortexHuman Brain AtlasWilliams syndromeSpectrum disorderConnectome approachVisuomotor impairmentFragile XSystems neuroscienceVisuomotorHuman brainCortexFunctional impairmentBiological basisPrader-WilliBrain atlasesExpression traitsNeuronal organizationGene expression traitsDisordersImpairmentNeural development
2017
Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children
Ortiz-Terán L, Diez I, Ortiz T, Perez D, Aragón J, Costumero V, Pascual-Leone A, Fakhri G, Sepulcre J. Brain circuit–gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6830-6835. PMID: 28607055, PMCID: PMC5495230, DOI: 10.1073/pnas.1619121114.Peer-Reviewed Original ResearchConceptsBlind childrenFunctional connectivity analysisMultisensory integration areasSensory deprivationFunctional connectivity relationshipsProtein gene familyNetwork connectivity profilesPrimary sensory cortexSystems-level analysisNeuroplastic adaptationsMultisensory cortexFunctional connectivityConnectivity analysisHuman neuroplasticityConnectivity changesGene expression profilesConnectivity profilesNeural reorganizationSensory cortexGene familySighted controlsHuman brainCortexBiological basisGenetic underpinnings