2017
The association between tau PET and retrospective cortical thinning in clinically normal elderly
LaPoint M, Chhatwal J, Sepulcre J, Johnson K, Sperling R, Schultz A. The association between tau PET and retrospective cortical thinning in clinically normal elderly. NeuroImage 2017, 157: 612-622. PMID: 28545932, PMCID: PMC5772972, DOI: 10.1016/j.neuroimage.2017.05.049.Peer-Reviewed Original ResearchConceptsTemporal regionsCortical thinningCortical ROIsCortical thicknessRetrospective longitudinal analysisRight temporal regionAssociated with neuronal lossBaseline ageNormal cohortNeuronal lossRate of cortical thinningLeft cuneusPathologyMedial temporal regionsVolumetric ROIsReference regionAtrophyThick cross-sectionsCortical regionsBilateral parahippocampal cortexLongitudinal atrophyLongitudinal analysisLeft superior temporal sulcusCortexBrain studies
2009
Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway
Sepulcre J, Goñi J, Masdeu J, Bejarano B, de Mendizábal N, Toledo J, Villoslada P. Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis: Evidence From Voxel-Based Analysis of T1 Lesions in the Visual Pathway. JAMA Neurology 2009, 66: 173-179. PMID: 19204153, DOI: 10.1001/archneurol.2008.562.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleus atrophyGM atrophyMultiple sclerosisOptic pathway lesionsOptical radiationWhite matterOptic radiation lesionsGray matterWM regionsRegional GM atrophyWhite matter lesionsLesion probability mapsVoxel-based analysisT1 lesionsPathway lesionsLateral geniculate nucleusRadiation lesionsPresence of lesionsMultiple Sclerosis CenterGray matter atrophyOptic pathwayMultiple sclerosis plaquesAtrophyLesionsAxonal injury
2008
Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
Toledo J, Sepulcre J, Salinas-Alaman A, García-Layana A, Murie-Fernandez M, Bejarano B, Villoslada P. Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Multiple Sclerosis Journal 2008, 14: 906-912. PMID: 18573835, DOI: 10.1177/1352458508090221.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerHeidelberg retinal tomographyOptical coherence tomographyMultiple sclerosisRetinal nerve fiber layer thickness measurementsRetinal nerve fiber layer atrophyRetinal nerve fiber layer thicknessCompare optical coherence tomographyNerve fiber layer atrophyNerve fiber layerAssociated with physical disabilityRetinal tomographyFiber layerCoherence tomographyAxonal lossNeurological examinationMatched controlsSymbol Digit Modalities TestTissue changesPatientsCognitive disabilitiesAtrophyMS evolutionDetect thinningTomography