2016
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
Sepulcre J, Schultz A, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson K. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. Journal Of Neuroscience 2016, 36: 7364-7374. PMID: 27413148, PMCID: PMC4945661, DOI: 10.1523/jneurosci.0639-16.2016.Peer-Reviewed Original ResearchConceptsHallmarks of AD pathologyAmyloid-bAlzheimer's diseaseAD pathologyHallmarks of Alzheimer's diseaseElderly human brainPositron emission tomographyBrain tissue lossHuman brainTau depositionCortical associationMatter profileCortical mantleGrey matter intensityTauSpatial patternsLocal-to-localTau positron emission tomographyCognitively normal individualsEmission tomographyCognitive symptomsHallmarksTemporal lobeNetwork analysisAssociation areas
2010
The Organization of Local and Distant Functional Connectivity in the Human Brain
Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo B, Buckner R. The Organization of Local and Distant Functional Connectivity in the Human Brain. PLOS Computational Biology 2010, 6: e1000808. PMID: 20548945, PMCID: PMC2883589, DOI: 10.1371/journal.pcbi.1000808.Peer-Reviewed Original ResearchConceptsFunctional connectivityDistant functional connectivityIntrinsic functional connectivityAtypical brain functionHuman brainCortical-cortical interactionsInformation-processing efficiencyHeteromodal association areasObserved propertiesLong path lengthBrain systemsBrain regionsProcessing demandsTask performanceBrain functionAssociation areasSensorimotor cortexFunctional couplingModule couplingInformation processingBrainPath lengthCouplingLocal connectivityNetwork measures