2021
Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
Kim C, Montal V, Diez I, Orwig W, Initiative A, Sepulcre J. Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging. Human Brain Mapping 2021, 42: 2990-3004. PMID: 33955621, PMCID: PMC8193537, DOI: 10.1002/hbm.25350.Peer-Reviewed Original ResearchConceptsCognitively normal older adultsAmyloid-betaPathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseTau depositionPositron emission tomographyGeneral cognitive impairmentTau neurofibrillary tanglesAlzheimer's diseaseNormal older adultsOlder adultsAmyloid-beta depositionCognitive test scoresTau pathogenesisAD vulnerable areasNeurofibrillary tanglesHeteromodal areasTau accumulationCognitive changesCognitive deteriorationCognitive impairmentCognitive declinePathological hallmarkPreclinical ADCognitive level
2009
Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Buckner R, Sepulcre J, Talukdar T, Krienen F, Liu H, Hedden T, Andrews-Hanna J, Sperling R, Johnson K. Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease. Journal Of Neuroscience 2009, 29: 1860-1873. PMID: 19211893, PMCID: PMC2750039, DOI: 10.1523/jneurosci.5062-08.2009.Peer-Reviewed Original ResearchConceptsIntrinsic functional connectivityCortical hubsFunctional connectivityPositron emission tomography amyloid imagingAlzheimer's diseaseActive task statesFunctional magnetic resonance imaging datasetsDefault networkPrefrontal cortexHeteromodal areasPosterior cingulateBrain areasAccurate reference mapAssociation cortexCortical network architectureTask statesOlder controlsInformation processingCortexAmyloid-beta depositionHuman cerebral cortexCerebral cortexPatterns of vulnerabilityConsensus estimateBrain diseases