2022
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller J, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2113641119. PMID: 35380901, PMCID: PMC9169643, DOI: 10.1073/pnas.2113641119.Peer-Reviewed Original ResearchConceptsDefault-mode networkFunctional connectivitySalience networkRetrospenial cortexFunctional segregationPosterior default-mode networkAmyloid-bDefault-mode network regionsHigher-order cognitive functionsEarly-onset AD dementiaTau pathologyMedial prefrontal cortexAnterior cingulate cortexDisrupting neural communicationGraph-based network analysisBrain functional architectureMedial temporal regionsFunctional networksAlzheimer's diseaseBrain functional connectivityPreclinical Alzheimer's diseasePrefrontal cortexTau burdenCingulate cortexEpisodic memory
2021
Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Cortical microstructure is associated with tau burden and predicts cognitive decline and clinical progression in healthy older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.053011.Peer-Reviewed Original ResearchCognitively-normal individualsCortical mean diffusivityCognitive declineMiddle-temporal gyrusHarvard Aging Brain StudyInferior temporal tauPreclinical Alzheimer Cognitive CompositeAging Brain StudyHealthy older adultsRegional cortical thicknessAmyloid-bShort-term cognitive declineDiffusion-weighted imagingBrain gray matterClinical progressionNeuronal injuryC-PiB PETCognitive compositeProgression to MCIGray-matterRegions-of-interestCognitive AssessmentFTP-PETPACC5Cortical thicknessAmyloid‐β and tau pathologies relate to distinctive brain dysconnectomics in autosomal‐dominant Alzheimer’s disease
Guzman‐Velez E, Diez I, Schoemaker D, Pardilla‐Delgado E, Fox‐Fuller J, Vila‐Castelar C, Baena A, Sperling R, Johnson K, Lopera F, Sepulcre J, Quiroz Y. Amyloid‐β and tau pathologies relate to distinctive brain dysconnectomics in autosomal‐dominant Alzheimer’s disease. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056134.Peer-Reviewed Original ResearchAmyloid-bWeighted-degreesTau pathologyAutosomal-dominant Alzheimer's diseaseNon-carriersAutosomal-dominant ADTau burdenPredicting disease riskTau seedsPresenilin-1Tau propagationPSEN-1AD progressionSignificance thresholdAlzheimer's diseaseTauGraph-based network analysisMutation carriersTau-PETPosterior cingulate cortexMutationsConnectivity mapsGenetically-determinedResting-state fMRINetwork analysisAssociation of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults
Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Amariglio R, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular Psychiatry 2021, 26: 7813-7822. PMID: 34588623, PMCID: PMC8873001, DOI: 10.1038/s41380-021-01290-z.Peer-Reviewed Original ResearchConceptsCortical mean diffusivityCognitive declineOlder adultsCognitively normal older adultsHarvard Aging Brain StudyCortical microstructureInferior temporal tauProgression to mild cognitive impairmentNormal older adultsBrain structural changesAmyloid-bAging Brain StudyCompound B PETLongitudinal cognitive declineAD-vulnerable regionsHippocampal atrophy ratesCognitively normal individualsAlzheimer's diseaseMild cognitive impairmentCognitive slopesStructural MRIEntorhinal tauCognitive AssessmentCognitive impairmentLongitudinal cognition
2020
The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease
Rodriguez‐Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz A, Properzi M, Scott M, Fortea J, Johnson K, Sperling R, Vannini P. The relationship between cortical microstructural changes and in vivo amyloid‐β and tau in aging and preclinical Alzheimer's disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.041626.Peer-Reviewed Original ResearchCortical mean diffusivityC-PiB PETTemporo-parietal brain regionsHarvard Aging Brain StudyAmyloid-bAlzheimer's diseaseMean diffusivityPreclinical stage of Alzheimer's diseaseAging Brain StudyGray matterPreclinical Alzheimer's diseaseStages of Alzheimer's diseaseCerebellar gray matterBrain regionsRegions-of-interestTemporal regionsSurface-based approachEntorhinal cortexBrain studiesGlial activationBrain microstructural propertiesLongitudinal studyCortical MDNon-linear trajectoriesCortical microstructure
2017
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive association
2016
In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain
Sepulcre J, Schultz A, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson K. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. Journal Of Neuroscience 2016, 36: 7364-7374. PMID: 27413148, PMCID: PMC4945661, DOI: 10.1523/jneurosci.0639-16.2016.Peer-Reviewed Original ResearchConceptsHallmarks of AD pathologyAmyloid-bAlzheimer's diseaseAD pathologyHallmarks of Alzheimer's diseaseElderly human brainPositron emission tomographyBrain tissue lossHuman brainTau depositionCortical associationMatter profileCortical mantleGrey matter intensityTauSpatial patternsLocal-to-localTau positron emission tomographyCognitively normal individualsEmission tomographyCognitive symptomsHallmarksTemporal lobeNetwork analysisAssociation areas
2015
A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease
Hu C, Cheng L, Sepulcre J, Johnson K, Fakhri G, Lu Y, Li Q. A Spectral Graph Regression Model for Learning Brain Connectivity of Alzheimer’s Disease. PLOS ONE 2015, 10: e0128136. PMID: 26024224, PMCID: PMC4449104, DOI: 10.1371/journal.pone.0128136.Peer-Reviewed Original ResearchConceptsNetwork featuresAlzheimer's diseaseConsistent with known pathologyUnknown graphConnection weightsReconstruction networkCortical hubsDegree statisticsData modelSmooth signalsFeatures of brain pathologyOptimization frameworkAmyloid-bPartial correlation estimationImage dataNetworkGraphGlobal connectivity measuresPositron emission tomographyConnectivity measuresNeurodegenerative diseasesConnectivity patternsSample correlationClinical ADSimulated data
2013
In vivo characterization of the early states of the amyloid-beta network
Sepulcre J, Sabuncu M, Becker A, Sperling R, Johnson K. In vivo characterization of the early states of the amyloid-beta network. Brain 2013, 136: 2239-2252. PMID: 23801740, PMCID: PMC3692037, DOI: 10.1093/brain/awt146.Peer-Reviewed Original ResearchConceptsAmyloid-bAlzheimer's diseasePittsburgh compound B positron emission tomography imagingPrecuneus/posterior cingulate cortexMedial temporal lobeRegional brain atrophyAlzheimer's disease pathologyAmyloid-betaOrbitofrontal cortexCingulate cortexAmygdala nucleiTemporal lobeCortical regionsAssociated with accumulationHub propertiesEmission tomography imagingNeurodegenerative diseasesBrain atrophyDisease pathologyAlzheimerHippocampusAbnormal accumulationCortexIn vivo characterizationElderly subjects