Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals
Schultz A, Chhatwal J, Hedden T, Mormino E, Hanseeuw B, Sepulcre J, Huijbers W, LaPoint M, Buckley R, Johnson K, Sperling R. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. Journal Of Neuroscience 2017, 37: 4323-4331. PMID: 28314821, PMCID: PMC5413178, DOI: 10.1523/jneurosci.3263-16.2017.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional connectivity MRITau neurofibrillary tanglesAssociated with <i>inTau-PETNeurofibrillary tanglesAmyloid pathologyCourse of preclinical ADTau levelsTau-PET signalTau PET tracersRegional tauTau PET imagingInferior temporalPreclinical ADMolecular pathologyTauReports of associationsAmyloid PET imagingCortical association networksInferior parietal cortexAmyloidAssociated with connectivityAssociation networksPreclinical Alzheimer's disease