2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAlleles
2018
Neurogenetic contributions to amyloid beta and tau spreading in the human cortex
Sepulcre J, Grothe M, d’Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang H, Jacobs H, Hanseeuw B, Li Q, El-Fakhri G, Sperling R, Johnson K. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine 2018, 24: 1910-1918. PMID: 30374196, PMCID: PMC6518398, DOI: 10.1038/s41591-018-0206-4.Peer-Reviewed Original ResearchConceptsAmyloid-betaGenetic profileIdentified distinct pathwaysTau positron emission tomography imagingTau propagationTau pathwayTau spreadingGenetic backgroundAllen Human Brain AtlasDistinct pathwaysAlzheimer's diseaseTauLipid metabolismAb accumulationAdult individualsPathwayHuman Brain AtlasPathological progressionTranscriptomeMechanisms of pathological progressionBetaAmyloidProteinopathiesNeuronal circuitsApoO3‐10‐05: ROBUST MOLECULAR PROPERTIES UNDERLYING REGIONAL VULNERABILITY TO AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
Jelistratova I, Sepulcre J, González-Escamilla G, Teipel S, Grothe M. O3‐10‐05: ROBUST MOLECULAR PROPERTIES UNDERLYING REGIONAL VULNERABILITY TO AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia 2018, 14: p1043-p1045. DOI: 10.1016/j.jalz.2018.06.2829.Peer-Reviewed Original Research
2017
Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain
Sepulcre J, Sabuncu M, Li Q, Fakhri G, Sperling R, Johnson K. Tau and amyloid β proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia 2017, 13: 1261-1269. PMID: 28366797, PMCID: PMC5623176, DOI: 10.1016/j.jalz.2017.02.011.Peer-Reviewed Original ResearchConceptsAging brainFunctional connectivityAlzheimer's disease-related pathologyCognitively normal individualsPositron emission tomography scanHyperconnected regionsFunctional network changesMisfolded tauDisease-related pathologyBrain areasEmission tomography scanAmyloid-bFunctional reorganizationB proteinHuman brainNeuronal circuitsTauBrainNeuronal functionNegative associationAmyloidCortical patternsNetwork changesElderly subjectsPositive associationPhases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals
Schultz A, Chhatwal J, Hedden T, Mormino E, Hanseeuw B, Sepulcre J, Huijbers W, LaPoint M, Buckley R, Johnson K, Sperling R. Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals. Journal Of Neuroscience 2017, 37: 4323-4331. PMID: 28314821, PMCID: PMC5413178, DOI: 10.1523/jneurosci.3263-16.2017.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional connectivity MRITau neurofibrillary tanglesAssociated with <i>inTau-PETNeurofibrillary tanglesAmyloid pathologyCourse of preclinical ADTau levelsTau-PET signalTau PET tracersRegional tauTau PET imagingInferior temporalPreclinical ADMolecular pathologyTauReports of associationsAmyloid PET imagingCortical association networksInferior parietal cortexAmyloidAssociated with connectivityAssociation networksPreclinical Alzheimer's disease