2024
Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patterns
2022
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
Montal V, Diez I, Kim C, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R, Bejanin A, Pegueroles J, Dols-Icardo O, Vannini P, El-Fakhri G, Johnson K, Sperling R, Fortea J, Sepulcre J. Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Science Translational Medicine 2022, 14: eabn7273. PMID: 35895837, PMCID: PMC9942690, DOI: 10.1126/scitranslmed.abn7273.Peer-Reviewed Original ResearchConceptsTau spreadingIntracellular accumulation of tau proteinAccumulation of tau proteinAlzheimer's diseasePathological tau accumulationGenetic gradientGenetic dataTau proteinNeurofibrillary tanglesSynaptic genesTau accumulationGenetic traitsGenesDrug development strategiesExpression gradientIntracellular accumulationTauExpressionCognitively normal older participantsHuman brain cortexTanglesProteinApoTraitsAlzheimer
2018
O3‐10‐05: ROBUST MOLECULAR PROPERTIES UNDERLYING REGIONAL VULNERABILITY TO AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
Jelistratova I, Sepulcre J, González-Escamilla G, Teipel S, Grothe M. O3‐10‐05: ROBUST MOLECULAR PROPERTIES UNDERLYING REGIONAL VULNERABILITY TO AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE. Alzheimer's & Dementia 2018, 14: p1043-p1045. DOI: 10.1016/j.jalz.2018.06.2829.Peer-Reviewed Original ResearchPET staging of amyloidosis using striatum
Hanseeuw B, Betensky R, Mormino E, Schultz A, Sepulcre J, Becker J, Jacobs H, Buckley R, LaPoint M, Vannini P, Donovan N, Chhatwal J, Marshall G, Papp K, Amariglio R, Rentz D, Sperling R, Johnson K, Initiative F, Study A. PET staging of amyloidosis using striatum. Alzheimer's & Dementia 2018, 14: 1281-1292. PMID: 29792874, PMCID: PMC6219621, DOI: 10.1016/j.jalz.2018.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmyloid beta-PeptidesAmyloidosisApolipoprotein E4Brain ConcussionCognitive DysfunctionCorpus StriatumDisease ProgressionFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedLongitudinal StudiesMalePositron-Emission TomographyProspective StudiesSeverity of Illness IndexConceptsPositron emission tomographyHippocampal volumeCortical amyloidInvolvement of cortexPositron emission tomography dataStriatal signalingPositron emission tomography classificationAmyloid positron emission tomographyStriatumCognitive declineCortical measuresCortexPostmortem dataCognitionCortical depositsEmission tomographyIncreased predictive powerDementia progressionAdvanced amyloidosisDementia researchAlzheimerPET dataStriatalFollow-up dataPredictive power
2013
In vivo characterization of the early states of the amyloid-beta network
Sepulcre J, Sabuncu M, Becker A, Sperling R, Johnson K. In vivo characterization of the early states of the amyloid-beta network. Brain 2013, 136: 2239-2252. PMID: 23801740, PMCID: PMC3692037, DOI: 10.1093/brain/awt146.Peer-Reviewed Original ResearchConceptsAmyloid-bAlzheimer's diseasePittsburgh compound B positron emission tomography imagingPrecuneus/posterior cingulate cortexMedial temporal lobeRegional brain atrophyAlzheimer's disease pathologyAmyloid-betaOrbitofrontal cortexCingulate cortexAmygdala nucleiTemporal lobeCortical regionsAssociated with accumulationHub propertiesEmission tomography imagingNeurodegenerative diseasesBrain atrophyDisease pathologyAlzheimerHippocampusAbnormal accumulationCortexIn vivo characterizationElderly subjects