2022
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals. Scientific Reports 2022, 12: 14307. PMID: 35995824, PMCID: PMC9395408, DOI: 10.1038/s41598-022-18325-2.Peer-Reviewed Original ResearchConceptsApolipoprotein epsilon 4Apolipoprotein epsilon 4 alleleAlzheimer's Disease Neuroimaging InitiativeApolipoprotein epsilon 4 carriersTau burdenAmyloid depositsAPOE4 non-carriersAssociated with amyloid depositionPresence of ApoE4 alleleCross-sectional studyRegional tau burdenAssess correlationsCognitively normal participantsIncreased amyloid burdenNormal cognitive functionCognitively normal older individualsStandardized uptake value ratioEpsilon 4AD-related biomarkersAPOE4 alleleTau depositionCortical thicknessAmyloidCarrier statusAlleles
2021
Longitudinal predictive modeling of tau progression along the structural connectome
Yang F, Chowdhury S, Jacobs H, Sepulcre J, Wedeen V, Johnson K, Dutta J. Longitudinal predictive modeling of tau progression along the structural connectome. NeuroImage 2021, 237: 118126. PMID: 33957234, PMCID: PMC8260445, DOI: 10.1016/j.neuroimage.2021.118126.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyTau progressionDiffusion tensor imagingLongitudinal predictive modelsAlzheimer's Disease Neuroimaging InitiativeAlzheimer's diseaseTau PET scansPositron emission tomographyLongitudinal positron emission tomographyTau neurofibrillary tanglesAging Brain StudyTau measuresNeurofibrillary tanglesTau transmissionStructural connectivity mapsPET scansCognitive declineBrain studiesPhysiological processesTensor imagingTauStructural connectomeGoodness of model fitClosed-form solutionPrediction framework
2018
Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology
Grothe M, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel S, Initiative A. Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology. Brain 2018, 141: 2755-2771. PMID: 30016411, PMCID: PMC6113636, DOI: 10.1093/brain/awy189.Peer-Reviewed Original ResearchConceptsRegional gene expression profilesGene expression profilesAlzheimer's disease pathologyExpression profilesPathophysiological mechanism of Alzheimer's diseaseDisease pathologyAlzheimer's diseaseAmyloid depositsExpression levelsMechanisms of Alzheimer's diseaseHuman brain transcriptomeGene set enrichment analysisTau kinasesAlzheimer's Disease Neuroimaging InitiativeMicroarray measurementsTau proteinMAPT expressionAllen Brain AtlasGene setsAmyloid precursorBrain transcriptomeRas-ERKNeurofibrillary degenerationRegionally selective vulnerabilityMitochondrial respiration
2011
The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease
Sabuncu M, Desikan R, Sepulcre J, Yeo B, Liu H, Schmansky N, Reuter M, Weiner M, Buckner R, Sperling R, Fischl B, Initiative F. The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease. JAMA Neurology 2011, 68: 1040-1048. PMID: 21825241, PMCID: PMC3248949, DOI: 10.1001/archneurol.2011.167.Peer-Reviewed Original ResearchConceptsMini-Mental State Examination scoreHippocampal volume lossMini-MentalDecreased cognitive performanceCognitive performanceExamination scoresCortical thinningCortical regionsMeasures of cognitive performanceMulticenter case-control studyBaseline hippocampal volumeRate of hippocampal volume lossStudies of neuroimagingMild cognitive impairmentCross-subject analysisAnnual rate of hippocampal volume lossAlzheimer's Disease Neuroimaging InitiativeStudy participantsDementia stagesVolume lossHippocampal volumeIndicators of ADCognitive impairmentHippocampal atrophyLongitudinal atrophy