The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults
Gagliardi G, Rodriguez‐Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz A, Properzi M, Papp K, Marshall G, Fortea J, Johnson K, Sperling R, Vannini P. The role of cortical microstructural changes on longitudinal accumulation of tau and cognitive decline in at risk older adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065744.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineOlder adultsCognitively-normal older adultsHarvard Aging Brain StudyAD-related cognitive declinePreclinical Alzheimer Cognitive CompositeCognitively-normal adultsAging Brain StudyAccumulation of tau pathologyAPOE e4 statusBrain microstructural changesCognitive compositeTau accumulationPACC5Gray-matterCognitive AssessmentCognitive impairmentFTP-PETAt-risk individualsAPOE-e4 carriersBrain studiesApo E4E4 statusMean diffusivity