2021
Impact of reconstruction parameters on lesion detection and localization in joint ictal/inter-ictal SPECT reconstruction
Onwanna J, Chantadisai M, Tepmongkol S, Fahey F, Ouyang J, Rakvongthai Y. Impact of reconstruction parameters on lesion detection and localization in joint ictal/inter-ictal SPECT reconstruction. Annals Of Nuclear Medicine 2021, 36: 24-32. PMID: 34559366, DOI: 10.1007/s12149-021-01680-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainEpilepsyFemaleHumansImage Processing, Computer-AssistedMalePhantoms, ImagingROC CurveSignal-To-Noise RatioTomography, Emission-Computed, Single-PhotonConceptsLocalization receiver operating characteristicsDetection performanceSubtraction methodJoint methodOptimization iterationsLesion detection performanceSPECT reconstructionEpileptic focus localizationLocalization receiver operating characteristic curvesDifferential imagingInter-ictalLesion detectionIterationPhantom dataConventional subtraction methodPerformanceImagesPatient datasetsReconstruction parametersImpact of reconstruction parametersFocus localizationSubtractionDetectionSPECT dataJoint reconstructionDetecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians
Petibon Y, Fahey F, Cao X, Levin Z, Sexton‐Stallone B, Falone A, Zukotynski K, Kwatra N, Lim R, Bar‐Sever Z, Chemli Y, Treves S, Fakhri G, Ouyang J. Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians. Medical Physics 2021, 48: 4249-4261. PMID: 34101855, DOI: 10.1002/mp.15033.Peer-Reviewed Original ResearchMeSH KeywordsChildDeep LearningHumansPhysiciansRetrospective StudiesTechnetium Tc 99m MedronateTomography, Emission-Computed, Single-PhotonConceptsSingle-photon emission computed tomographyLow back painLumbar lesionsPediatric patientsTc-MDPEvaluate low back painCause of low back painTc-MDP scanLesion-presentEmission computed tomographyConvolutional neural networkClinical likelihoodBack painInterreader variabilityDeep convolutional neural networkLumbar locationLesionsStress lesionsFocal lesionsDeep learningPatientsLumbar stressPhysiciansDL systemsLROC studies
2018
Joint reconstruction of rest/stress myocardial perfusion SPECT
Lai X, Petibon Y, Fakhri G, Ouyang J. Joint reconstruction of rest/stress myocardial perfusion SPECT. Physics In Medicine And Biology 2018, 63: 135019. PMID: 29897044, PMCID: PMC6245543, DOI: 10.1088/1361-6560/aacc2f.Peer-Reviewed Original ResearchMeSH KeywordsHumansImage Processing, Computer-AssistedModels, TheoreticalMyocardial Perfusion ImagingMyocardiumPhantoms, ImagingSignal-To-Noise RatioTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingSingle photon emission computed tomographyReversible defectsSignal-to-noise ratioRest/stress SPECT myocardial perfusion imagingSPECT myocardial perfusion imagingConventional subtraction methodDefect detectionJoint methodPhoton emission computed tomographySubtraction methodReverse mappingClinical dose levelsEmission computed tomographyImprove defect detectionLow noiseNon-invasive assessmentClinical dosePerfusion defectsReduced doseImprove radiologists' performanceReconstruction frameworkRest imagesPerfusion imagingDose levels
2017
Joint reconstruction of Ictal/inter‐ictal SPECT data for improved epileptic foci localization
Rakvongthai Y, Fahey F, Borvorntanajanya K, Tepmongkol S, Vutrapongwatana U, Zukotynski K, Fakhri G, Ouyang J. Joint reconstruction of Ictal/inter‐ictal SPECT data for improved epileptic foci localization. Medical Physics 2017, 44: 1437-1444. PMID: 28211105, PMCID: PMC5462456, DOI: 10.1002/mp.12167.Peer-Reviewed Original ResearchMeSH KeywordsEpilepsies, PartialHumansImage Processing, Computer-AssistedPhantoms, ImagingSignal-To-Noise RatioSubtraction TechniqueTomography, Emission-Computed, Single-PhotonConceptsSPECT reconstruction methodDifferential imagingLow-noise datasetConventional subtraction methodLesion contrastSPECT projection dataEpileptic focus localizationHoffman phantomPatient studiesReconstruction methodJoint methodSPECT projectionsHead phantomPhantom locationsSubtraction methodPhantom studyNuclear medicine physiciansAttenuation backgroundPhantomConventional subtraction approachFocus localizationConventional subtractionReceiver operating characteristicLow noiseProjection data
2013
Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies
Rakvongthai Y, Fakhri G, Lim R, Bonab A, Ouyang J. Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies. Medical Physics 2013, 40: 102506. PMID: 24089927, PMCID: PMC3785531, DOI: 10.1118/1.4820977.Peer-Reviewed Original ResearchMeSH Keywords3-IodobenzylguanidineAlgorithmsHumansImage Processing, Computer-AssistedMonte Carlo MethodMultimodal ImagingNeoplasmsPhantoms, ImagingTechnetium Tc 99m MedronateTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsScatter correctionDual-radionuclideContrast recoveryPhantom studyAnthropomorphic torso phantomPatient studiesTumor uptakeTumor imagingSPECT projectionsTorso phantomMonte-CarloPhantom dataPhantomIterative reconstructionOSEMProjection dataDR dataIncrease patient throughputNoise realizationsSPECT-CTImage reconstructionClinical studiesTumorTumor projectionPoisson noise
2010
Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects
Trott C, Ouyang J, Fakhri G. Comparison of simultaneous and sequential SPECT imaging for discrimination tasks in assessment of cardiac defects. Physics In Medicine And Biology 2010, 55: 6897-6910. PMID: 21048290, PMCID: PMC3117301, DOI: 10.1088/0031-9155/55/22/019.Peer-Reviewed Original ResearchMeSH KeywordsDiagnosis, DifferentialFatty AcidsHeart DiseasesHumansInjectionsIodobenzenesMyocardial InfarctionROC CurveTechnetium Tc 99m SestamibiTime FactorsTomography, Emission-Computed, Single-PhotonDual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism
El Fakhri G, Ouyang J. Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism. Methods In Molecular Biology 2010, 680: 237-246. PMID: 21153385, DOI: 10.1007/978-1-60761-901-7_16.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainDiagnosis, DifferentialDopamineHumansImage Processing, Computer-AssistedMonte Carlo MethodNeural Networks, ComputerOrganotechnetium CompoundsParkinsonian DisordersTomography, Emission-Computed, Single-PhotonTropanesConceptsDopamine transporter functionBrain SPECTDifferential diagnosis of parkinsonismDifferential diagnosisDiagnosis of parkinsonismIdiopathic Parkinson's diseaseDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of idiopathic Parkinson's diseaseCorticobasal degenerationProgressive supranuclear palsyParkinson's diseaseMultiple system atrophyParkinsonSPECT protocol
2009
Quantitative simultaneous cardiac SPECT using MC‐JOSEM
Ouyang J, Zhu X, Trott C, Fakhri G. Quantitative simultaneous cardiac SPECT using MC‐JOSEM. Medical Physics 2009, 36: 602-611. PMID: 19292000, PMCID: PMC2673670, DOI: 10.1118/1.3063544.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsFatty AcidsHeartImage Processing, Computer-AssistedIodobenzenesMonte Carlo MethodPhantoms, ImagingSensitivity and SpecificityTechnetium Tc 99m SestamibiTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMEnergy windowWater-filled torso phantomScatter correctionPhotopeak energy windowStandard OSEMCardiac SPECT imagingActivity concentration ratioIterative reconstruction algorithmReconstruction algorithmMyocardium wallTorso phantomActivity estimationDetector responseEmission energyBackground compartmentPhantom dataCardiac SPECTActivity distributionRest/stress imagingScatteringCases of patientsOSEMChest painCardiac protocols
2008
Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT
Ouyang J, Fakhri G, Moore S. Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT. Medical Physics 2008, 35: 2029-2040. PMID: 18561679, PMCID: PMC2673642, DOI: 10.1118/1.2907561.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsEquipment DesignImage Processing, Computer-AssistedIndium RadioisotopesLungModels, StatisticalMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedReproducibility of ResultsScattering, RadiationSoftwareTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMWater-filled torso phantomMC scatter estimationTriple-energy-windowActivity estimationIterative reconstruction algorithmTorso phantomPhantom studyBackground compartmentScatter estimationActivity distributionAverage relative biasPhantomReconstruction algorithmActivity concentrationsSynthetic projectionsSphere locationScattering
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging
Ouyang J, Fakhri G, Moore S. Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging. Medical Physics 2007, 34: 3263-3272. PMID: 17879789, DOI: 10.1118/1.2756601.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainDopamineHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIodine RadioisotopesMonte Carlo MethodPhotonsRadionuclide ImagingRadiopharmaceuticalsSensitivity and SpecificityTechnetiumTomography, Emission-Computed, Single-PhotonConceptsMC-JOSEMEnergy windowFast Monte CarloSignal-to-noise ratioScatter correction methodOrdered-subsets expectation-maximizationMonte CarloOrdered-subsets expectation-maximization algorithmIterative reconstruction algorithmPrimary photonsReconstruction algorithmPhoton transportSeptal penetrationDetector responseMC simulationsIterative reconstructionAttenuation distributionStandard OSEMPhotonsProjection dataPatient-specific activityDetectorReconstructed imagesScatteringEstimation of scattering
2006
Generalized five‐dimensional dynamic and spectral factor analysis
Fakhri G, Sitek A, Zimmerman R, Ouyang J. Generalized five‐dimensional dynamic and spectral factor analysis. Medical Physics 2006, 33: 1016-1024. PMID: 16696478, DOI: 10.1118/1.2179168.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsCorpus StriatumDopamineHaplorhiniHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalParkinson DiseaseReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-Photon
2005
Performance of a novel collimator for high‐sensitivity brain SPECT
Fakhri G, Ouyang J, Zimmerman R, Fischman A, Kijewski M. Performance of a novel collimator for high‐sensitivity brain SPECT. Medical Physics 2005, 33: 209-215. PMID: 16485427, DOI: 10.1118/1.2143140.Peer-Reviewed Original ResearchMeSH KeywordsBrainEquipment DesignEquipment Failure AnalysisHumansImage EnhancementPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsSphere activity concentrationNPW-SNRStandard collimatorSphere-to-background activity ratiosAttenuation of countsPhantom centerActivity concentrationsPoint spread functionCentral regionCollimatorPhantom studyStriatal phantomCylindrical backgroundResolution recoveryPhantomSpherical lesionsRamp filterCrystal surfaceSpread functionSignal-to-noise ratioCentral brain structuresFitting imageHealthy volunteersBrain SPECTSphere activity