2023
Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
Yang Y, Zheng C, Chen B, Hernandez N, Faust P, Cai Z, Louis E, Matuskey D. Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density. The Cerebellum 2023, 23: 1053-1060. PMID: 37783917, DOI: 10.1007/s12311-023-01611-8.Peer-Reviewed Original ResearchSynaptic vesicle glycoprotein 2AAge-matched controlsSynaptic densityEssential tremorDentate nucleusCerebellar cortexET casesPilot studyLower synaptic densityPrevalent neurological diseaseNumerous degenerative changesNeuropathological alterationsMild atrophyNeuropathological studiesSynaptic markersMethodsThe current studyPostmortem studiesDegenerative changesNeuroimaging signaturesET patientsNeurological diseasesCerebellumEvidence of reductionCortexAtrophy
2022
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases
Tong J, Chen B, Tan P, Kurpiewski S, Cai Z. Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases. Frontiers In Medicine 2022, 9: 1062432. PMID: 36438061, PMCID: PMC9685622, DOI: 10.3389/fmed.2022.1062432.Peer-Reviewed Original ResearchPositron emission tomographyCentral nervous systemCNS diseaseNeurological disordersCentral nervous system diseaseNoninvasive positron emission tomographyNervous system diseasesIntense DNA damagePlausible therapeutic targetTherapeutic responseInflammatory responseSystem diseasesTherapeutic targetNervous systemNeurological diseasesEmission tomographyDiseasePARP1/2 inhibitorsPoly (ADP-ribose) polymeraseExpression levelsImaging targetsDisordersDNA damagePARP1/2Inflammation