2023
Injectable ice slurry for reducing pericardial adipose tissue
Shuhaiber J, Tuchayi S, Bijari F, Guehl N, Wang Y, Farinelli W, Arkun K, Fakhri G, Anderson R, Garibyan L. Injectable ice slurry for reducing pericardial adipose tissue. Lasers In Surgery And Medicine 2023, 55: 674-679. PMID: 37464943, DOI: 10.1002/lsm.23709.Peer-Reviewed Original ResearchConceptsPericardial adipose tissuePericardial adipose tissue volumeChest computed tomographyPAT volumeBaseline chest computed tomographyAnimal modelsSubcutaneous adipose tissue volumesCardiovascular diseaseHigh risk of cardiovascular diseaseAdipose tissueLow patient complianceRisk of cardiovascular diseaseWeight lossPreclinical large animal modelAdipose tissue volumeLarge animal modelBariatric surgeryComputed tomographyPatient complianceHigh riskNovel treatmentTreated groupCT imagesTissue volumeCryolipolysis
2022
PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study
Detmer F, Alpert N, Moon S, Dhaynaut M, Guerrero J, Guehl N, Xing F, Brugarolas P, Shoup T, Normandin M, Pelletier-Galarneau M, El Fakhri G, Petibon Y. PET imaging of mitochondrial function in acute doxorubicin-induced cardiotoxicity: a proof-of-principle study. Scientific Reports 2022, 12: 6122. PMID: 35414642, PMCID: PMC9005533, DOI: 10.1038/s41598-022-10004-6.Peer-Reviewed Original ResearchConceptsLeft anterior descending coronary arteryDoxorubicin-induced cardiotoxicityCardiac membrane potentialDoxorubicin infusionMembrane potentialAnimal modelsAcute doxorubicin-induced cardiotoxicityLeft anterior descending coronary artery territoryAcute cardiotoxic effectsAnterior descending coronary arteryControl saline infusionDescending coronary arteryDoxorubicin doseSaline infusionTest infusionCardiotoxic effectsMitochondrial membrane potentialInfusion catheterCoronary arteryInfusionMitochondrial functionDoxorubicinMyocardial areaPET imagingIntracoronary catheter
2021
Quantification of Myocardial Mitochondrial Membrane Potential Using PET
Pelletier-Galarneau M, Detmer F, Petibon Y, Normandin M, Ma C, Alpert N, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Current Cardiology Reports 2021, 23: 70. PMID: 33970353, PMCID: PMC8443083, DOI: 10.1007/s11886-021-01500-8.Peer-Reviewed Original Research