2021
Quantification of Myocardial Mitochondrial Membrane Potential Using PET
Pelletier-Galarneau M, Detmer F, Petibon Y, Normandin M, Ma C, Alpert N, El Fakhri G. Quantification of Myocardial Mitochondrial Membrane Potential Using PET. Current Cardiology Reports 2021, 23: 70. PMID: 33970353, PMCID: PMC8443083, DOI: 10.1007/s11886-021-01500-8.Peer-Reviewed Original Research
2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentrationBlebs in intracranial aneurysms: prevalence and general characteristics
Ashkezari S, Detmer F, Mut F, Chung B, Yu A, Stapleton C, See A, Amin-Hanjani S, Charbel F, Jahromi B, Niemelä M, Frösen J, Zhou J, Maiti S, Robertson A, Cebral J. Blebs in intracranial aneurysms: prevalence and general characteristics. Journal Of NeuroInterventional Surgery 2020, 13: 226-230. PMID: 32680877, PMCID: PMC8294207, DOI: 10.1136/neurintsurg-2020-016274.Peer-Reviewed Original ResearchConceptsAssociated with dental infectionDental infectionsIntracranial aneurysmsPercentage of aneurysmsHormone therapyPresence of blebsAssociated with hormone replacement therapyHormone replacement therapyHistory of hypertensionInternal carotid arteryReplacement therapyClinical factorsAneurysmVascular reconstructionCarotid arteryAneurysm neckRisk factorsMultiple blebsTherapyAngiographic imagesNeckInfectionRupture risk factorsBlebsHypertensionIncorporating variability of patient inflow conditions into statistical models for aneurysm rupture assessment
Detmer F, Mut F, Slawski M, Hirsch S, Bijlenga P, Cebral J. Incorporating variability of patient inflow conditions into statistical models for aneurysm rupture assessment. Acta Neurochirurgica 2020, 162: 553-566. PMID: 32008209, PMCID: PMC7172014, DOI: 10.1007/s00701-020-04234-8.Peer-Reviewed Original ResearchConceptsFlow conditionsCFD simulationsComputational hemodynamicsComputed flow fieldSteady CFD simulationsInflow boundary conditionsFlow variationsInflow conditionsRupture assessmentFlow fieldCFD dataAneurysm rupture predictionRupture predictionInflow rateBoundary conditionsCFDInfluence of inter-FlowHemodynamic parametersSimulation
2019
Comparison of statistical learning approaches for cerebral aneurysm rupture assessment
Detmer F, Lückehe D, Mut F, Slawski M, Hirsch S, Bijlenga P, von Voigt G, Cebral J. Comparison of statistical learning approaches for cerebral aneurysm rupture assessment. International Journal Of Computer Assisted Radiology And Surgery 2019, 15: 141-150. PMID: 31485987, DOI: 10.1007/s11548-019-02065-2.Peer-Reviewed Original ResearchConceptsSupport vector machineK-nearest neighborLinear support vector machineMultilayer perceptronRandom forestRBF-SVMMachine learningDecision treeTrained support vector machineNeural network classifierArea under the receiver operating characteristic curveStatistical learning approachNetwork classifierRBF kernelML classifiersPatient-related informationK-nearestVector machineClassifierLearning approachAneurysm rupture statusRupture statusTest casesReceiver operating characteristic curveResultsThe area under the receiver operating characteristic curveExtending statistical learning for aneurysm rupture assessment to Finnish and Japanese populations using morphology, hemodynamics, and patient characteristics.
Detmer F, Hadad S, Chung B, Mut F, Slawski M, Juchler N, Kurtcuoglu V, Hirsch S, Bijlenga P, Uchiyama Y, Fujimura S, Yamamoto M, Murayama Y, Takao H, Koivisto T, Frösen J, Cebral J. Extending statistical learning for aneurysm rupture assessment to Finnish and Japanese populations using morphology, hemodynamics, and patient characteristics. Neurosurgical FOCUS 2019, 47: e16. PMID: 31261120, PMCID: PMC7132362, DOI: 10.3171/2019.4.focus19145.Peer-Reviewed Original ResearchConceptsArea under the receiver operating characteristic curveFinnish patientsPatient populationRisks associated with treatmentReceiver operating characteristic curveRupture riskInteraction termsAneurysm characteristicsIncidental aneurysmsModels' area under the receiver operating characteristic curvePatient characteristicsMultiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment
Berg P, Voß S, Janiga G, Saalfeld S, Bergersen A, Valen-Sendstad K, Bruening J, Goubergrits L, Spuler A, Chiu T, Tsang A, Copelli G, Csippa B, Paál G, Závodszky G, Detmer F, Chung B, Cebral J, Fujimura S, Takao H, Karmonik C, Elias S, Cancelliere N, Najafi M, Steinman D, Pereira V, Piskin S, Finol E, Pravdivtseva M, Velvaluri P, Rajabzadeh-Oghaz H, Paliwal N, Meng H, Seshadhri S, Venguru S, Shojima M, Sindeev S, Frolov S, Qian Y, Wu Y, Carlson K, Kallmes D, Dragomir-Daescu D, Beuing O. Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment. International Journal Of Computer Assisted Radiology And Surgery 2019, 14: 1795-1804. PMID: 31054128, DOI: 10.1007/s11548-019-01986-2.Peer-Reviewed Original ResearchConceptsHemodynamic simulationsWall shear stressFlow characteristicsShear stressAspect ratioMultiple vorticesFlow resultsRupture probabilitySimulation setupSimulation capabilitiesSimulation approachInflow jetSimulationRuptured aneurysmsState-of-the-artHemodynamic quantificationIntracranial aneurysmsLocal Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.
Cebral J, Detmer F, Chung B, Choque-Velasquez J, Rezai B, Lehto H, Tulamo R, Hernesniemi J, Niemela M, Yu A, Williamson R, Aziz K, Shakur S, Amin-Hanjani S, Charbel F, Tobe Y, Robertson A, Frösen J. Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall. American Journal Of Neuroradiology 2019, 40: 510-516. PMID: 30733253, PMCID: PMC6420361, DOI: 10.3174/ajnr.a5970.Peer-Reviewed Original ResearchConceptsWall shear stressOscillatory shear indexGradient oscillatory numberOscillatory wall shear stressShear stressShear indexRelative residence timeWall shear stress gradientAverage wall shear stressFlow conditionsComputational fluid dynamics modelThin regionShear stress gradientLocal hemodynamicsFluid dynamics modelRecirculation zoneSwirling flowResidence timeStress gradientAneurysm hemodynamicsImpingement siteDynamic pressureAneurysm regionDynamic modelFlow stream
2018
Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location
Detmer F, Chung B, Jimenez C, Hamzei-Sichani F, Kallmes D, Putman C, Cebral J. Associations of hemodynamics, morphology, and patient characteristics with aneurysm rupture stratified by aneurysm location. Neuroradiology 2018, 61: 275-284. PMID: 30456458, PMCID: PMC6403015, DOI: 10.1007/s00234-018-2135-9.Peer-Reviewed Original ResearchConceptsHigh wall shear stressWall shear stressOscillatory shearAdverse hemodynamic environmentShear stressComplex flowHemodynamic environmentComplex shapesImage-based modelingIrregular shapeMorphologySidewall aneurysmsBifurcationFlowSidewallShearShapeAdverse hemodynamicsMiddle cerebral arteryInternal carotid arteryExternal validation of cerebral aneurysm rupture probability model with data from two patient cohorts
Detmer F, Fajardo-Jiménez D, Mut F, Juchler N, Hirsch S, Pereira V, Bijlenga P, Cebral J. External validation of cerebral aneurysm rupture probability model with data from two patient cohorts. Acta Neurochirurgica 2018, 160: 2425-2434. PMID: 30374656, PMCID: PMC6290995, DOI: 10.1007/s00701-018-3712-8.Peer-Reviewed Original ResearchDevelopment and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics
Detmer F, Chung B, Mut F, Slawski M, Hamzei-Sichani F, Putman C, Jiménez C, Cebral J. Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics. International Journal Of Computer Assisted Radiology And Surgery 2018, 13: 1767-1779. PMID: 30094777, PMCID: PMC6328054, DOI: 10.1007/s11548-018-1837-0.Peer-Reviewed Original ResearchConceptsArea under the curveAneurysm locationMaximum oscillatory shear indexImage-based computational fluid dynamicsOscillatory shear indexComputational fluid dynamicsLow shear areaRisk of surgeryShear areaAdverse hemodynamic environmentShear indexFluid dynamicsHemodynamic environmentGeometric parametersPatient ageEndovascular treatmentIncreased rupture riskSubarachnoid hemorrhageAneurysm ruptureUnruptured aneurysmsPatient characteristicsTreatment strategiesInternal validityMale genderPatient genderDevelopment of a statistical model for discrimination of rupture status in posterior communicating artery aneurysms
Detmer F, Chung B, Mut F, Pritz M, Slawski M, Hamzei-Sichani F, Kallmes D, Putman C, Jimenez C, Cebral J. Development of a statistical model for discrimination of rupture status in posterior communicating artery aneurysms. Acta Neurochirurgica 2018, 160: 1643-1652. PMID: 29922867, PMCID: PMC6309378, DOI: 10.1007/s00701-018-3595-8.Peer-Reviewed Original ResearchConceptsWall shear stressComputational fluid dynamicsMinimum wall shear stressArterial wall shear stressImage-based computational fluid dynamicsShear stressFluid dynamicsGeometric parametersGeometric characteristicsNon-sphericity indexFlow velocityUnruptured PCOM aneurysmsBulge locationStatistical modelShear
2017
Virtual and Augmented Reality Systems for Renal Interventions: A Systematic Review
Detmer F, Hettig J, Schindele D, Schostak M, Hansen C. Virtual and Augmented Reality Systems for Renal Interventions: A Systematic Review. IEEE Reviews In Biomedical Engineering 2017, 10: 78-94. PMID: 28885161, DOI: 10.1109/rbme.2017.2749527.Peer-Reviewed Original ResearchConceptsRenal interventionTreatment of renal cell carcinomaClinical practiceRenal cell carcinomaRenal stone treatmentRenal cell carcinoma treatmentSystematic literature searchSystematic review's purposePartial nephrectomyCell carcinomaRenal stonesCarcinoma treatmentClinical studiesStone treatmentInclusion criteriaAugmented reality systemLiterature searchReality systemClinical environmentIdentified literatureTreatmentInterventionReview purposesAngioarchitectures and Hemodynamic Characteristics of Posterior Communicating Artery Aneurysms and Their Association with Rupture Status
Chung B, Doddasomayajula R, Mut F, Detmer F, Pritz M, Hamzei-Sichani F, Brinjikji W, Kallmes D, Jimenez C, Putman C, Cebral J. Angioarchitectures and Hemodynamic Characteristics of Posterior Communicating Artery Aneurysms and Their Association with Rupture Status. American Journal Of Neuroradiology 2017, 38: 2111-2118. PMID: 28860212, PMCID: PMC5690887, DOI: 10.3174/ajnr.a5358.Peer-Reviewed Original ResearchConceptsWall shear stressShear stressMinimum wall shear stressWall shear stress distributionOscillatory wall shear stressRegions of elevated wall shear stressImage-based computational fluid dynamicsElevated wall shear stressFlow patternsShear stress distributionComputational fluid dynamicsInflow jetStress distributionFluid dynamicsAneurysm hemodynamicsHemodynamic characteristicsJetArtery bifurcationFlowRupture riskSidewallStressCharacteristics