2020
Blebs in intracranial aneurysms: prevalence and general characteristics
Ashkezari S, Detmer F, Mut F, Chung B, Yu A, Stapleton C, See A, Amin-Hanjani S, Charbel F, Jahromi B, Niemelä M, Frösen J, Zhou J, Maiti S, Robertson A, Cebral J. Blebs in intracranial aneurysms: prevalence and general characteristics. Journal Of NeuroInterventional Surgery 2020, 13: 226-230. PMID: 32680877, PMCID: PMC8294207, DOI: 10.1136/neurintsurg-2020-016274.Peer-Reviewed Original ResearchConceptsAssociated with dental infectionDental infectionsIntracranial aneurysmsPercentage of aneurysmsHormone therapyPresence of blebsAssociated with hormone replacement therapyHormone replacement therapyHistory of hypertensionInternal carotid arteryReplacement therapyClinical factorsAneurysmVascular reconstructionCarotid arteryAneurysm neckRisk factorsMultiple blebsTherapyAngiographic imagesNeckInfectionRupture risk factorsBlebsHypertension
2019
Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment
Berg P, Voß S, Janiga G, Saalfeld S, Bergersen A, Valen-Sendstad K, Bruening J, Goubergrits L, Spuler A, Chiu T, Tsang A, Copelli G, Csippa B, Paál G, Závodszky G, Detmer F, Chung B, Cebral J, Fujimura S, Takao H, Karmonik C, Elias S, Cancelliere N, Najafi M, Steinman D, Pereira V, Piskin S, Finol E, Pravdivtseva M, Velvaluri P, Rajabzadeh-Oghaz H, Paliwal N, Meng H, Seshadhri S, Venguru S, Shojima M, Sindeev S, Frolov S, Qian Y, Wu Y, Carlson K, Kallmes D, Dragomir-Daescu D, Beuing O. Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment. International Journal Of Computer Assisted Radiology And Surgery 2019, 14: 1795-1804. PMID: 31054128, DOI: 10.1007/s11548-019-01986-2.Peer-Reviewed Original ResearchConceptsHemodynamic simulationsWall shear stressFlow characteristicsShear stressAspect ratioMultiple vorticesFlow resultsRupture probabilitySimulation setupSimulation capabilitiesSimulation approachInflow jetSimulationRuptured aneurysmsState-of-the-artHemodynamic quantificationIntracranial aneurysmsLocal Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.
Cebral J, Detmer F, Chung B, Choque-Velasquez J, Rezai B, Lehto H, Tulamo R, Hernesniemi J, Niemela M, Yu A, Williamson R, Aziz K, Shakur S, Amin-Hanjani S, Charbel F, Tobe Y, Robertson A, Frösen J. Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall. American Journal Of Neuroradiology 2019, 40: 510-516. PMID: 30733253, PMCID: PMC6420361, DOI: 10.3174/ajnr.a5970.Peer-Reviewed Original ResearchConceptsWall shear stressOscillatory shear indexGradient oscillatory numberOscillatory wall shear stressShear stressShear indexRelative residence timeWall shear stress gradientAverage wall shear stressFlow conditionsComputational fluid dynamics modelThin regionShear stress gradientLocal hemodynamicsFluid dynamics modelRecirculation zoneSwirling flowResidence timeStress gradientAneurysm hemodynamicsImpingement siteDynamic pressureAneurysm regionDynamic modelFlow stream
2018
Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics
Detmer F, Chung B, Mut F, Slawski M, Hamzei-Sichani F, Putman C, Jiménez C, Cebral J. Development and internal validation of an aneurysm rupture probability model based on patient characteristics and aneurysm location, morphology, and hemodynamics. International Journal Of Computer Assisted Radiology And Surgery 2018, 13: 1767-1779. PMID: 30094777, PMCID: PMC6328054, DOI: 10.1007/s11548-018-1837-0.Peer-Reviewed Original ResearchConceptsArea under the curveAneurysm locationMaximum oscillatory shear indexImage-based computational fluid dynamicsOscillatory shear indexComputational fluid dynamicsLow shear areaRisk of surgeryShear areaAdverse hemodynamic environmentShear indexFluid dynamicsHemodynamic environmentGeometric parametersPatient ageEndovascular treatmentIncreased rupture riskSubarachnoid hemorrhageAneurysm ruptureUnruptured aneurysmsPatient characteristicsTreatment strategiesInternal validityMale genderPatient gender
2017
Angioarchitectures and Hemodynamic Characteristics of Posterior Communicating Artery Aneurysms and Their Association with Rupture Status
Chung B, Doddasomayajula R, Mut F, Detmer F, Pritz M, Hamzei-Sichani F, Brinjikji W, Kallmes D, Jimenez C, Putman C, Cebral J. Angioarchitectures and Hemodynamic Characteristics of Posterior Communicating Artery Aneurysms and Their Association with Rupture Status. American Journal Of Neuroradiology 2017, 38: 2111-2118. PMID: 28860212, PMCID: PMC5690887, DOI: 10.3174/ajnr.a5358.Peer-Reviewed Original ResearchMeSH KeywordsAneurysm, RupturedHemodynamicsHumansHydrodynamicsIntracranial AneurysmMaleRisk FactorsStress, MechanicalConceptsWall shear stressShear stressMinimum wall shear stressWall shear stress distributionOscillatory wall shear stressRegions of elevated wall shear stressImage-based computational fluid dynamicsElevated wall shear stressFlow patternsShear stress distributionComputational fluid dynamicsInflow jetStress distributionFluid dynamicsAneurysm hemodynamicsHemodynamic characteristicsJetArtery bifurcationFlowRupture riskSidewallStressCharacteristics