Skip to Main Content

Phosphate, PTH, and FGF23 as mediators of the rachitic growth plate

Research Faculty and Summary

Marie Demay, MD

Dr. Demay’s CORT-supported study is focused on identifying the molecular basis for susceptibility of chondrocytes to phosphate-mediated apoptosis. This work characterizes hormone and growth factor (PTH, FGF23 and 1,25-dihydroxyvitamin D) effects on phosphate-mediated apoptosis using in vitro and in vivo models.

Download Entire Publication as PDF

Growth plate histology

Growth plate histology at 16, 21 and 35 days of age.  Mice were weaned to a 2% calcium, 1.25% phosphorus and 20% lactose diet at 18 days of age.

(Copyright 2010, The Endocrine Society. This image first appeared as part of a figure in Endocrinology, 151(10):4607-12, October 2010: "The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice," SU Miedlich, ED Zhu, Y Sabbagh and MB Demay.)