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Phosphate, PTH, and FGF23 as mediators of the rachitic growth plate

Research Faculty and Summary

Marie Demay, MD

Dr. Demay’s CORT-supported study is focused on identifying the molecular basis for susceptibility of chondrocytes to phosphate-mediated apoptosis. This work characterizes hormone and growth factor (PTH, FGF23 and 1,25-dihydroxyvitamin D) effects on phosphate-mediated apoptosis using in vitro and in vivo models.

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Growth plate histology at 16, 21 and 35 days of age. Mice were weaned to a 2% calcium, 1.25% phosphorus and 20% lactose diet at 18 days of age.

(Copyright 2010, The Endocrine Society. This image first appeared as part of a figure in Endocrinology, 151(10):4607-12, October 2010: "The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout mice," SU Miedlich, ED Zhu, Y Sabbagh and MB Demay.)