2003
Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation
Borg MA, Tamborlane WV, Shulman GI, Sherwin RS. Local Lactate Perfusion of the Ventromedial Hypothalamus Suppresses Hypoglycemic Counterregulation. Diabetes 2003, 52: 663-666. PMID: 12606506, DOI: 10.2337/diabetes.52.3.663.Peer-Reviewed Original ResearchConceptsCounterregulatory hormone responsesVentromedial hypothalamusHormone responseSprague-Dawley ratsGlucose-sensing mechanismHypoglycemic counterregulationSystemic hypoglycemiaHormonal suppressionLactate perfusionApproximate fourfold increaseGlucose metabolismMicrodialysis perfusionGlucose perfusionHormonal responsesHypoglycemic plateauHypoglycemiaPerfusionL-lactateExogenous glucoseFourfold increaseGlucoseLactate
2002
Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia?
Monsod TP, Flanagan DE, Rife F, Saenz R, Caprio S, Sherwin RS, Tamborlane WV. Do Sensor Glucose Levels Accurately Predict Plasma Glucose Concentrations During Hypoglycemia and Hyperinsulinemia? Diabetes Care 2002, 25: 889-893. PMID: 11978686, DOI: 10.2337/diacare.25.5.889.Peer-Reviewed Original Research
2000
Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls.
Enoksson S, Talbot M, Rife F, Tamborlane WV, Sherwin RS, Caprio S. Impaired in vivo stimulation of lipolysis in adipose tissue by selective beta2-adrenergic agonist in obese adolescent girls. Diabetes 2000, 49: 2149-2153. PMID: 11118019, DOI: 10.2337/diabetes.49.12.2149.Peer-Reviewed Original ResearchConceptsSubcutaneous abdominal adipose tissueAbdominal adipose tissueBeta2-adrenergic agonistObese adolescent girlsGlycerol releaseAdipose tissueBMI 21Lean girlsObese womenObese girlsSelective beta2-adrenergic agonistAdolescent girlsSignificant differencesMobilization of fatBMI 36Lean womenAdrenergic systemLipolytic sensitivityAdolescent obesityLipolytic effectVivo stimulationBMI 38AgonistsWomenObesity
1999
Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Borg MA, Borg WP, Tamborlane WV, Brines ML, Shulman GI, Sherwin RS. Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats. Diabetes 1999, 48: 584-587. PMID: 10078560, DOI: 10.2337/diabetes.48.3.584.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamusSystemic hypoglycemiaChronic hypoglycemiaCellular glucopeniaDefective counterregulationDiabetic BBNondiabetic BBDiabetic groupEpinephrine responseNorepinephrine responseCatecholamine responsesIatrogenic hypoglycemiaDiabetic ratsGlucagon releaseEfferent pathwaysSympathoadrenal systemControl ratsHypoglycemic ratsHypoglycemiaGlucopeniaCounterregulationRatsHypothalamusPerfusionCritical role
1997
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. Journal Of Clinical Investigation 1997, 99: 361-365. PMID: 9006005, PMCID: PMC507804, DOI: 10.1172/jci119165.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamic nucleusMM D-glucoseControl groupGlucose perfusionHypoglycemic counterregulationSystemic hypoglycemiaNorepinephrine releaseGlucagon secretionCatecholamine concentrationsHypothalamic nucleiAwake ratsHormonal secretionControl animalsHypoglycemiaHormonal responsesPerfusionL glucoseCounterregulationD-glucoseGlucagonRatsSecretionGlucoseAnimalsGlucopenia