2004
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents. New England Journal Of Medicine 2004, 350: 2362-2374. PMID: 15175438, DOI: 10.1056/nejmoa031049.Peer-Reviewed Original ResearchMeSH KeywordsAdiponectinAdolescentAdultChildChild, PreschoolC-Reactive ProteinFemaleFollow-Up StudiesGlucose Tolerance TestHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsInterleukin-6Logistic ModelsMaleMetabolic SyndromeObesityPrevalenceProteinsRisk FactorsSeverity of Illness IndexConceptsDegree of obesityC-reactive proteinMetabolic syndromeBody mass indexAdiponectin levelsInsulin resistanceBlood pressureStandard glucose tolerance testC-reactive protein levelsHigh-density lipoprotein cholesterolZ-scoreAdverse cardiovascular outcomesSeverity of obesityGlucose tolerance testLevels of triglyceridesCardiovascular outcomesLipoprotein cholesterolObese subjectsObese childrenUnit of increaseMultiracial cohortNonobese childrenPlasma lipidsChildhood obesityObesity
1996
Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations
Caprio S, Tamborlane WV, Silver D, Robinson C, Leibel R, McCarthy S, Grozman A, Belous A, Maggs D, Sherwin RS. Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations. American Journal Of Physiology 1996, 271: e626-e630. PMID: 8843759, DOI: 10.1152/ajpendo.1996.271.3.e626.Peer-Reviewed Original ResearchConceptsVisceral fat massLeptin levelsLeptin concentrationsFat depotsJuvenile obesityFat massInsulin concentrationsDb/db miceHyperglycemic clamp studiesAdult obese subjectsOb gene productDevelopment of obesityFa/fa ratsLeptin mRNA expressionSubcutaneous fat depotsMagnetic resonance imagingSpecific fat depotsObese subjectsNonobese subjectsObese childrenDb miceNonobese childrenAcute increaseObese stateHyperinsulinemic conditions
1994
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels
Caprio S, Cline G, Boulware S, Permanente C, Shulman GI, Sherwin RS, Tamborlane WV. Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. American Journal Of Physiology 1994, 266: e885-e891. PMID: 8023918, DOI: 10.1152/ajpendo.1994.266.6.e885.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusIDDM adolescentsEffect of pubertyGlucose metabolismNondiabetic groupIDDM subjectsInsulin infusionHealthy controlsLeucine fluxHealthy young adult controlsLow-dose insulin infusionPlasma free fatty acid levelsFree fatty acid levelsYoung adult controlsFatty acid levelsAction of insulinLeucine oxidation rateAmino acid/protein metabolismEuglycemic hyperinsulinemiaDiabetes mellitusInsulin resistanceInsulin valuesBasal glucosePlasma insulinNormal puberty