2023
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials
Zinter M, Markovic D, Asaro L, Nadkarni V, McQuillen P, Sinha P, Matthay M, Jeschke M, Agus M, Sapru A, Agus M, Coughlin-Wells K, Hughes K, French J, Fitzgerald M, Srinivasan V, Sisko M, Chima R, Howard K, Jones R, Thomas N, Spear D, Li S, Pinto A, Eldridge P, Newth C, Kwok J, Hassinger A, Qiao H, Bysani K, Monjure T, Faustino E, Tala J, Kandil S, Quinn T, Hirshberg E, Lilley J, Wintergerst K, Sullivan J, Lee K, Schwarz A, Flores C, Vargas-Shiraishi O, Sorce L, Marsillio L, Shukla A, Cvijanovich N, Flori H, Brumfield B, Stone C, Dahmer M, Jayachandran C, Federman M, Wong K, Vangala S, Pellegrini M, Balliu B, Gala K, Kirkpatrick T, Deshmukh T, Mareboina M, Do N, Ashtari N, Ratiu A, Nett S, Singleton M, Jarvis D, McNally M, Martini K, Pinto N, Chong G, Rodgers C, Viteri S, John R, Mulholland T, Pellicciotti G, Sapru A, McQuillen P, Zinter M, Goel S, Alkhouli M, McKenzie A, Villarreal-Chico D. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 945-949. PMID: 36656551, PMCID: PMC10111993, DOI: 10.1164/rccm.202210-1988le.Peer-Reviewed Original Research
2021
Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT)
Hirshberg E, Alexander J, Asaro L, Coughlin-Wells K, Steil G, Spear D, Stone C, Nadkarni V, Agus M, Investigators H, Agus M, Wypij D, Asaro L, Nadkarni V, Srinivasan V, Biagas K, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Luckett P, Fackler J, Rozen T. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). CHEST Journal 2021, 160: 919-928. PMID: 33932465, PMCID: PMC8449010, DOI: 10.1016/j.chest.2021.04.049.Peer-Reviewed Original ResearchConceptsLung Failure-Pediatric INsulin Titration trialBlood glucose targetsCritical care trialsManagement of hyperglycemiaTitration trialCare trialsGlucose targetsCDS toolElectronic clinical decision support systemLow complianceBlood glucose metricsIll pediatric patientsObservational retrospective studyElectronic decision support systemClinical decision support systemInotropic supportPediatric patientsPatient factorsRetrospective studyClinician factorsIll childrenGlucose metricsPatientsTherapeutic interventionsStudy design
2017
Tight Glycemic Control in Critically Ill Children
Agus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood GlucoseCardiovascular Surgical ProceduresChildChild, PreschoolCritical IllnessFemaleGlucoseHospital MortalityHumansHyperglycemiaHypoglycemic AgentsInfantInfant, NewbornInsulinIntensive Care Units, PediatricIntention to Treat AnalysisLength of StayMalePostoperative PeriodConceptsHigher-target groupLower-target groupTight glycemic controlBlood glucose levelsGlycemic controlIll childrenGlucose levelsCardiac surgeryHealth care-associated infectionsICU-free daysVentilator-free daysCritically Ill ChildrenNormal blood glucose levelsIntensive care unitCare-associated infectionsSafety monitoring boardAverage glucose levelsHigh rateContinuous glucose monitoringIll adultsOrgan dysfunctionPrimary outcomeSevere hypoglycemiaTreat analysisCare unit