2021
Neuroprotection through G-CSF: recent advances and future viewpoints
Rahi V, Jamwal S, Kumar P. Neuroprotection through G-CSF: recent advances and future viewpoints. Pharmacological Reports 2021, 73: 372-385. PMID: 33389706, DOI: 10.1007/s43440-020-00201-3.Peer-Reviewed Original ResearchConceptsGranulocyte-colony stimulating factorNeutrophilic granulocyte lineageNumerous cell typesJAK/STATG-CSF receptorPI3K/AktInhibition of apoptosisTransduction pathwaysHaemopoietic stem cellsMAP kinaseNeuronal differentiationHematopoietic stemCell typesGranulocyte lineageNeurological disordersStem cellsProgenitor cellsRecent pre-clinical studiesHematopoietic growth factorsAttractive targetChemotherapy-associated neutropeniaStimulation of neurogenesisObserved neuroprotective effectsDifferentiationPre-clinical studies
2019
Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors.
Jamwal S, Mittal A, Kumar P, Alhayani DM, Al-Aboudi A. Therapeutic Potential of Agonists and Antagonists of A1, A2a, A2b and A3 Adenosine Receptors. Current Pharmaceutical Design 2019, 25: 2892-2905. PMID: 31333104, DOI: 10.2174/1381612825666190716112319.Peer-Reviewed Original ResearchConceptsCentral nervous systemNervous systemFast excitatory postsynaptic currentsCerebral blood flowExcitatory postsynaptic currentsPeripheral nervous systemAntagonists of A1Pharmacology of adenosineA3 adenosine receptorAutonomic gangliaPostsynaptic currentsReceptor agonistMetabolic dysfunctionBlood flowNeuronal activityOcular diseasesSynaptic terminalsTherapeutic strategiesAdenosine receptorsTherapeutic potentialChemical transmissionATP actsExtracellular concentrationReceptors vizNerve signals
2015
Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism
Jamwal S, Singh S, Kaur N, Kumar P. Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism. Neurotoxicity Research 2015, 28: 171-184. PMID: 26078029, DOI: 10.1007/s12640-015-9535-y.Peer-Reviewed Original ResearchConceptsQuinolinic acidBody weightQA treatmentGABAergic medium spiny neuronsN-methyl-D-aspartate receptorsOxidative stressGABAergic neuronal lossPro-inflammatory levelsHyperkinetic movement disordersExcitotoxic cell deathAnti-inflammatory propertiesExcitotoxic neuronal deathMedium spiny neuronsReceptor antagonistic propertiesNeuroinflammatory mechanismsPossible neurotransmittersNeuroinflammatory markersNeuronal lossNeuroprotective effectsNeurotransmitter alterationsCatecholamine levelsCascade of eventsNeuronal deathSpiny neuronsMovement disorders