2015
Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism
Singh S, Jamwal S, Kumar P. Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochemical Research 2015, 40: 1758-1766. PMID: 26160706, DOI: 10.1007/s11064-015-1658-2.Peer-Reviewed Original ResearchConceptsProtective effectPresence of piperineChronic treatmentMotor deficitsNeuroprotective effectsNeurochemical abnormalitiesAbstract3-Nitropropionic acidPresent studyInduced neurotoxicityMotor functionNeuroprotective activityBody weightMolecular alterationsBeneficial effectsHuntington's diseaseOxidative stressNatural polyphenolNeurotoxicityCurcuminPiperineRatsDiseaseAdministrationBehavioral parametersDays
2014
Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats
Khan A, Jamwal S, Bijjem K, Prakash A, Kumar P. Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid-induced neurotoxicity in rats. Neuroscience 2014, 287: 66-77. PMID: 25536048, DOI: 10.1016/j.neuroscience.2014.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody WeightCorpus StriatumEncephalitisGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHeme Oxygenase-1HeminLipid PeroxidationLithium ChlorideMaleMetalloporphyrinsMotor ActivityNeuroprotective AgentsNeurotoxicity SyndromesNitritesNitro CompoundsOxidative StressPropionatesProtoporphyrinsRatsRats, WistarRotarod Performance TestSignal TransductionConceptsAdministration of heminHemeoxygenase-1GSK-3β activityN-methyl-D-aspartate receptorsOxidative stressPro-inflammatory mediatorsPresent studyHO-1 inhibitorGSK-3β pathwaySynthase kinase-3β pathwayDifferent neurodegenerative disordersHD-like symptomsProphylactic therapyNeuroprotective effectsPathophysiology of HDTin protoporphyrinMotor impairmentPharmacological modulationMotor coordinationBody weightLocomotor activityMolecular alterationsTherapeutic potentialOxidative burdenNeurodegenerative disorders