2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progression
2017
Behavioral Tests for Rodent Models
Jamwal S, Singh S, Bansal P. Behavioral Tests for Rodent Models. 2017, 315-341. DOI: 10.1007/978-981-10-5981-0_21.Peer-Reviewed Original ResearchMotor coordinationPerformance-based testsTraumatic brain injuryBrain injuryBehavioral testsTesting of drugsMotor activityRotating rodRotarod testGrip strengthMovement disordersRodent modelsAnimal modelsExperimental drugsPreclinical researchDrugsDisordersRodentsTestLatencyResearchRotarodInjuryCoordination