2024
Nutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson’s Disease: Elixir for the Brain
Soni D, Jamwal S, Chawla R, Singh S, Singh D, Singh T, Khurana N, Kanwal A, Dureja H, Patil U, Singh R, Kumar P. Nutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson’s Disease: Elixir for the Brain. Food Reviews International 2024, 40: 3079-3102. DOI: 10.1080/87559129.2024.2337766.Peer-Reviewed Original ResearchPre-clinicalGut-brain axisProtein ubiquitinationParkinson's diseaseMitochondrial dysfunctionSignaling pathwayMolecular mechanismsRelieve PD symptomsSymptoms of PDClinical trialsHealth benefits of nutraceuticalsBenefits of nutraceuticalsCustomized therapyClinical aspectsExpression of PDMediterranean dietNeurotransmitter imbalanceNeuroprotective mechanismsNeuroprotective potentialOxidative stressDiseasePD symptomsHealth benefitsSymptomsUbiquitin
2023
Animal models of Huntington’s disease and their applicability to novel drug discovery and development
Upadhayay S, Jamwal S, Kumar P. Animal models of Huntington’s disease and their applicability to novel drug discovery and development. Expert Opinion On Drug Discovery 2023, 18: 527-538. PMID: 37042034, DOI: 10.1080/17460441.2023.2201493.Peer-Reviewed Original ResearchConceptsHD animal modelsAnimal modelsHuntington's diseaseNon-motor symptomsProgressive neurodegenerative disorderDrug therapyDisease progressionPreclinical phaseLoss of functionNeurodegenerative disordersClinical phaseDrug discoveryDiseaseNovel drug discoveryHuntingtin geneToxic gainCAG trinucleotide repeatDrugsProgressionHD geneEnormous progressionAn Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development
Upadhayay S, Yedke N, Rahi V, Singh S, Kumar S, Arora A, Chandolia P, Kaur P, Kumar M, Koshal P, Jamwal S, Kumar P. An Overview of the Pathophysiological Mechanisms of 3-Nitropropionic Acid (3-NPA) as a Neurotoxin in a Huntington's Disease Model and Its Relevance to Drug Discovery and Development. Neurochemical Research 2023, 48: 1631-1647. PMID: 36738367, DOI: 10.1007/s11064-023-03868-1.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsAnimal modelsGABAergic medium spiny neuronsDisease modelsKey clinical manifestationsHuntington's disease modelsPathogenesis of diseaseWeb of ScienceClinical manifestationsPathophysiological mechanismsSpiny neuronsPreclinical studiesMotor impairmentLike symptomsTherapeutic targetExperimental animalsExcessive productionHuntington's diseaseOxidative stressDiseasePathogenic conditionsDrug discoveryMitochondrial functionFree radicalsNeurotoxin
2021
Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Sex-based disparity in paraoxonase-2 expression in the brains of African green monkeys. Free Radical Biology And Medicine 2021, 167: 201-204. PMID: 33722626, PMCID: PMC8096713, DOI: 10.1016/j.freeradbiomed.2021.03.003.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParaoxonase 2Parkinson's diseaseBrain regionsGreen monkeysOxidative stressReactive oxygen speciesAnti-inflammatory propertiesSex-based disparitiesParaoxonase-2 expressionDifferent brain regionsNigrostriatal systemPON2 expressionDevelopment of therapeuticsNeurodegenerative disordersDiseaseProtein levelsROS levelsLower ROS levelsMitochondrial performanceSex-based variationDisordersMonkeysOxygen speciesMales
2020
PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders
Jamwal S, Blackburn J, Elsworth JD. PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders. Pharmacology & Therapeutics 2020, 219: 107705. PMID: 33039420, PMCID: PMC7887032, DOI: 10.1016/j.pharmthera.2020.107705.Peer-Reviewed Original ResearchConceptsNeurodegenerative disordersParkinson's diseaseAlzheimer's diseaseParaoxonase 2Mitochondrial biogenesisNeurodegenerative diseasesHuntington's diseasePeroxisome proliferator-activated receptorProliferator-activated receptorPotential therapeutic targetDevastating neurological disorderFunction of neuronsPeroxisome proliferator-activated receptor gamma co-activator-1 alphaPharmacological-based therapiesSymptomatic treatmentCurrent therapiesClinical trialsLigand-inducible transcription factorsTherapeutic targetNeurological disordersDiseasePPARγ modulatorsProgressive lossMitochondrial dysfunctionPromising target
2019
Insight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson’s Disease and Huntington’s Disease: A Review
Jamwal S, Kumar P. Insight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson’s Disease and Huntington’s Disease: A Review. Current Neuropharmacology 2019, 17: 165-175. PMID: 29512464, PMCID: PMC6343208, DOI: 10.2174/1570159x16666180302115032.Peer-Reviewed Original ResearchConceptsParkinson's diseaseHuntington's diseaseStriatal neurotransmittersNeuronal deathNeurotransmitter levelsAltered neurotransmitters levelBasal ganglia regionsExcitotoxic neuronal deathNeurotransmitter alterationsBrain dopaminePathophysiological basisBasal gangliaGanglia regionsMovement disordersPreclinical studiesReceptor densitySpecific drugsCoordinated body movementsDiseaseNeurotransmittersAltered levelsOxidative stressExact mechanismMitochondrial dysfunctionImportant neurotransmitter
2017
Chapter 19 Animal Models of Inflammatory Bowel Disease
Jamwal S, Kumar P. Chapter 19 Animal Models of Inflammatory Bowel Disease. 2017, 467-477. DOI: 10.1016/b978-0-12-809468-6.00019-x.Peer-Reviewed Original ResearchInflammatory bowel diseaseAnimal modelsBowel diseasePathologic mechanismsHuman inflammatory bowel diseaseImmune system overactivationDifferent animal modelsIntestinal inflammationClinical featuresInflammatory conditionsMucosal barrierClinical studiesGut microbiotaSmall intestineCellular alterationsOxidative stressDisease assessmentDiseaseMolecular assessmentAlterationsDate overviewInflammationDrug discoveryPathophysiologyColon
2016
Tetrabenazine: Spotlight on Drug Review
Kaur N, Kumar P, Jamwal S, Deshmukh R, Gauttam V. Tetrabenazine: Spotlight on Drug Review. Annals Of Neurosciences 2016, 23: 176-185. PMID: 27721587, PMCID: PMC5043267, DOI: 10.1159/000449184.Peer-Reviewed Original ResearchTreatment of choreaHyperkinetic disorderOnly US FoodVesicular monoamine transporter 2Further clinical trialsMonoamine transporter 2Treatment of psychosisMechanism of actionClinical efficacyTardive dyskinesiaClinical trialsClinical studiesMonoamine storesTourette syndromeDrug AdministrationUS FoodHuntington's choreaChoreaTherapeutic potentialTetrabenazineTransporter 2Huntington's diseaseAdverse effectsLack of awarenessDisease
2015
Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats
Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P. Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington's disease in rats. Toxicology Reports 2015, 2: 1222-1232. PMID: 28962465, PMCID: PMC5598492, DOI: 10.1016/j.toxrep.2015.08.004.Peer-Reviewed Original ResearchHuntington's diseaseEthanol extractTreatment of HDBeneficial effectsNon-motor dysfunctionPro-inflammatory mediatorsMedium spiny neuronsExperimental Huntington's diseaseMitochondrial functionRice bran extractBehavioral parametersProphylactic therapyNeurochemical estimationsNeurochemical alterationsProgressive motorPresent studySpiny neuronsAnimal modelsNeurochemical levelsOxidative burdenNeurodegenerative disordersBran extractDiseaseMitochondrial dysfunctionSignificant alterationsPiperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism
Singh S, Jamwal S, Kumar P. Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism. Neurochemical Research 2015, 40: 1758-1766. PMID: 26160706, DOI: 10.1007/s11064-015-1658-2.Peer-Reviewed Original ResearchConceptsProtective effectPresence of piperineChronic treatmentMotor deficitsNeuroprotective effectsNeurochemical abnormalitiesAbstract3-Nitropropionic acidPresent studyInduced neurotoxicityMotor functionNeuroprotective activityBody weightMolecular alterationsBeneficial effectsHuntington's diseaseOxidative stressNatural polyphenolNeurotoxicityCurcuminPiperineRatsDiseaseAdministrationBehavioral parametersDays