Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours
Weinzimer S, Homan S, Ferry R, Moshang T. Serum IGF‐I and IGFBP‐3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. Clinical Endocrinology 1999, 51: 339-345. PMID: 10469014, DOI: 10.1046/j.1365-2265.1999.00804.x.Peer-Reviewed Original ResearchConceptsIGF-binding protein-3Hypothalamic/chiasmatic gliomaIGFBP-3 levelsGrowth hormone deficiencyBody mass indexPrimitive neuroectodermal tumorHypothalamic-chiasmatic gliomaProvocative GH testingIGFBP-3 concentrationsIGF-I levelsGH deficiencyGH testingHormone deficiencySerum IGFBrain tumorsPubertal stageTumor typesLower IGFBP-3 levelsNormal IGF-1 levelsLow IGF-I levelsGrowth factor insulin-like growth factorInsulin-like growth factorIGF-1 levelsRetrospective case reviewBone age delayCellular Actions of Insulin-Like Growth Factor Binding Proteins
Ferry R, Katz L, Grimberg A, Cohen P, Weinzimer S. Cellular Actions of Insulin-Like Growth Factor Binding Proteins. Hormone And Metabolic Research 1999, 31: 192-202. PMID: 10226802, PMCID: PMC4151550, DOI: 10.1055/s-2007-978719.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisGene Expression Regulation, NeoplasticHumansInsulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IIConceptsInsulin-like growth factorFree insulin-like growth factorInsulin-like growth factor binding proteinGrowth factorCleavage of IGFBPsIGF-dependent actionsGrowth factor binding proteinFactor binding proteinPotent mitogenic agentsIGFBP proteasesIGF axisIGF receptorIGFBPsCellular actionsMitogenic agentsModulate levelsCellular proliferationCell growthBinding proteinSomatic growthHigh affinityProteinReceptors