2001
Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1
Weinzimer S, Gibson T, Collett-Solberg P, Khare A, Liu B, Cohen P. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. PMID: 11297622, DOI: 10.1210/jcem.86.4.7380.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serumTransferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein
Weinzimer SA. Transferrin Is an Insulin-Like Growth Factor-Binding Protein-3 Binding Protein. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1806-1813. DOI: 10.1210/jc.86.4.1806.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsApoptosisCarrier ProteinsCell DivisionCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding ProteinsIronKineticsMaleMicroscopy, ConfocalMuscle, SmoothProstatic NeoplasmsSheepTissue DistributionTransferrinUrinary BladderYeastsConceptsIGFBP-3IGFBP-3-induced apoptosisInsulin-like growth factorBladder smooth muscle cellsHuman liver complementary DNA libraryProstate cancer cellsSmooth muscle cellsImportant physiological effectsIGF actionBinding proteinProteins/receptorsMuscle cellsProtein 3Growth factorCancer cellsCell proliferationTF treatmentPhysiological effectsNegligible affinityHuman serum
2000
Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*
Liu B, Lee H, Weinzimer S, Powell D, Clifford J, Kurie J, Cohen P. Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis*. Journal Of Biological Chemistry 2000, 275: 33607-33613. PMID: 10874028, DOI: 10.1074/jbc.m002547200.Peer-Reviewed Original ResearchConceptsIGFBP-3Insulin-like growth factor-binding protein-3IGFBP-3-induced apoptosisInsulin-like growth factor-binding proteinsGrowth factor-binding proteinsRXR response elementsNuclear receptor retinoid X receptorFactor-binding proteinProstate cancer cellsReceptor retinoid X receptorRetinoid X receptorX receptorProtein 3Direct functional interactionCancer cellsRXR ligandsTranscriptional signalingApoptosisResponse elementTranscriptional activityFunctional interactionSignalingKnockout cellsCellsReceptorsHuman Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3
Mannhardt B, Weinzimer S, Wagner M, Fiedler M, Cohen P, Jansen-Dürr P, Zwerschke W. Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3. Molecular And Cellular Biology 2000, 20: 6483-6495. PMID: 10938125, PMCID: PMC86123, DOI: 10.1128/mcb.20.17.6483-6495.2000.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBlotting, NorthernCell DivisionCell LineCells, CulturedDose-Response Relationship, DrugFluorescent Antibody TechniqueGlutathione TransferaseHumansInsulin-Like Growth Factor Binding Protein 3KeratinocytesOncogene Proteins, ViralPapillomavirus E7 ProteinsPrecipitin TestsProtein BindingRecombinant Fusion ProteinsTime FactorsTransfectionTumor Cells, CulturedTumor Suppressor Protein p53Two-Hybrid System Techniques
1999
Cellular Actions of Insulin-Like Growth Factor Binding Proteins
Ferry R, Katz L, Grimberg A, Cohen P, Weinzimer S. Cellular Actions of Insulin-Like Growth Factor Binding Proteins. Hormone And Metabolic Research 1999, 31: 192-202. PMID: 10226802, PMCID: PMC4151550, DOI: 10.1055/s-2007-978719.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree insulin-like growth factorInsulin-like growth factor binding proteinGrowth factorCleavage of IGFBPsIGF-dependent actionsGrowth factor binding proteinFactor binding proteinPotent mitogenic agentsIGFBP proteasesIGF axisIGF receptorIGFBPsCellular actionsMitogenic agentsModulate levelsCellular proliferationCell growthBinding proteinSomatic growthHigh affinityProteinReceptors