2013
The Impact of Insulin Pharmacokinetics and Pharmacodynamics on the Closed-loop Artificial Pancreas
Lee J, Dassau E, Zisser H, Tamborlane W, Weinzimer S, Doyle F. The Impact of Insulin Pharmacokinetics and Pharmacodynamics on the Closed-loop Artificial Pancreas. 2013, 127-132. DOI: 10.1109/cdc.2013.6759870.Peer-Reviewed Original ResearchInsulin delivery optionsPK/PD characteristicsClinical performanceArtificial pancreasPK/PDMeal disturbance rejectionClosed-loop artificial pancreasPharmacodynamic characteristicsClinical resultsGlucose regulationInsulin pharmacokineticsDelivery optionsPancreasOptionsUniversity of VirginiaMetabolic simulatorPharmacodynamicsPharmacokinetics
2008
Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas
Weinzimer SA, Steil GM, Swan KL, Dziura J, Kurtz N, Tamborlane WV. Fully Automated Closed-Loop Insulin Delivery Versus Semiautomated Hybrid Control in Pediatric Patients With Type 1 Diabetes Using an Artificial Pancreas. Diabetes Care 2008, 31: 934-939. PMID: 18252903, DOI: 10.2337/dc07-1967.Peer-Reviewed Original ResearchConceptsType 1 diabetesGlucose levelsHCl groupFCL groupInsulin pumpBeta cell replacement therapyPostprandial glycemic excursionsPostprandial glucose excursionsPostprandial glucose levelsClosed-loop glucose controlArtificial pancreasClosed-loop artificial pancreasPediatric patientsPostprandial excursionsBolus dosesGlycemic excursionsReplacement therapySubcutaneous routeGlucose controlGlucose excursionsInsulin delivery systemsHybrid closed-loop controlInsulin absorptionType 1Dl