2024
ECI biocommentary: Samuel J. Gentle
Gentle S. ECI biocommentary: Samuel J. Gentle. Pediatric Research 2024, 1-1. PMID: 39548296, DOI: 10.1038/s41390-024-03739-7.Peer-Reviewed Original ResearchImproving Time to Goals of Care Discussions in Invasively Ventilated Preterm Infants.
Gentle S, Cohen C, Carlo W, Winter L, Hallman M. Improving Time to Goals of Care Discussions in Invasively Ventilated Preterm Infants. Pediatrics 2024, 154 PMID: 39359206, PMCID: PMC11524032, DOI: 10.1542/peds.2024-066585.Peer-Reviewed Original ResearchConceptsPostmenstrual ageBronchopulmonary dysplasiaPreterm infantsTracheostomy placementWeeks' PMA.Identifying preterm infantsWeeks postmenstrual ageBPD infantsTracheostomy dependenceInvasive ventilationGoC discussionsVentilatory requirementsTracheostomyVentilator liberationInfantsHospital dischargeMultidisciplinary conferenceQuality improvement initiativesWeeksChart analysisUniversity of AlabamaSMART aimStatistical process control chartsProcess control chartsControl chart analysisTeleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial
Gentle S, Trulove S, Rockwell N, Rutledge C, Gaither S, Norwood C, Wallace E, Carlo W, Tofil N. Teleneonatal or routine resuscitation in extremely preterm infants: a randomized simulation trial. Pediatric Research 2024, 1-7. PMID: 39341942, DOI: 10.1038/s41390-024-03545-1.Peer-Reviewed Original ResearchNeonatal resuscitationBag-mask ventilationQuality of resuscitationRoutine resuscitationNo-flow fractionResuscitation groupDelivery outcomesChest compressionsAdverse delivery outcomesQuality of neonatal resuscitationHigh-risk deliveriesAssociated with survivalHospital settingQuality of chest compressionsTime to intubationPreterm infantsNewborn resuscitationSingle-centerEpinephrine administrationLow failure rateResultsFifty-onePrimary outcomeSecondary outcomesResuscitationSimulated resuscitationHome is where the right ventricle lives: bronchopulmonary dysplasia-associated pulmonary hypertension and home ventilation
Gentle S, Ambalavanan N. Home is where the right ventricle lives: bronchopulmonary dysplasia-associated pulmonary hypertension and home ventilation. Pediatric Research 2024, 1-2. PMID: 39266628, DOI: 10.1038/s41390-024-03550-4.Peer-Reviewed Original ResearchAchieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants. Archives Of Disease In Childhood 2024, 109: 941-947. PMID: 38937062, PMCID: PMC11503043, DOI: 10.1136/archdischild-2024-327014.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionOxygen saturation indexSurvival statusPreterm infantsPulmonary hypertensionHigher FiOLt;29 weeks' gestationFraction of inspired oxygenWeeks postmenstrual ageSingle-centre studyNon-invasive predictorCase-control studyPostmenstrual ageWeeks gestationBronchopulmonary dysplasiaRespiratory supportNon-survivorsInfantsOxygen saturationPatient outcomesPretermSurvivalHypertensionWeeksPredictorsIdentification of Pulmonary Vascular Disease in Preterm Infants Using Oxygen Saturation Index
Gentle S, Carlo W, Ambalavanan N. Identification of Pulmonary Vascular Disease in Preterm Infants Using Oxygen Saturation Index. 2024, a6188-a6188. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6188.Peer-Reviewed Original Research525 Reducing adverse delivery outcomes through teleneonatology: a randomized simulation trial
Gentle S, Trulove S, Rockwell N, Rutledge C, Gaither S, Norwood C, Carlo W, Tofil N. 525 Reducing adverse delivery outcomes through teleneonatology: a randomized simulation trial. The American Journal Of The Medical Sciences 2024, 367: s314-s315. DOI: 10.1016/s0002-9629(24)00577-9.Peer-Reviewed Original Research737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes?
Gentle S, Carlo W, Ambalavanan N. 737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes? The American Journal Of The Medical Sciences 2024, 367: s461-s462. DOI: 10.1016/s0002-9629(24)00787-0.Peer-Reviewed Original Research
2023
Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis
Ramanand P, Indic P, Gentle S, Ambalavanan N. Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis. 2016 Computing In Cardiology Conference (CinC) 2023, 50: 1-4. DOI: 10.22489/cinc.2023.354.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionCardiorespiratory networkComplications of PHHeart ratePH groupMechanisms of disease progressionRespiratory rateDisease progressionPretermInfantsOxygen saturationCardiorespiratory morbidityHypertensionGroupMean delayDysplasiaComplicationsMorbidityInformation based similarity analysis of oxygen saturation recordings to detect Pulmonary hypertension in preterm infants
Ramanand P, Indic P, Gentle S, Ambalavanan N. Information based similarity analysis of oxygen saturation recordings to detect Pulmonary hypertension in preterm infants. Biomedical Signal Processing And Control 2023, 86: 105358. PMID: 37692106, PMCID: PMC10487283, DOI: 10.1016/j.bspc.2023.105358.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPulmonary hypertensionPreterm infantsClinical course of infantsDetect pulmonary hypertensionCourse of infantsPrevalence of PHManagement of PHOxygen saturation recordingsAssociated with multiple morbiditiesRisk of mortalityOxygen saturation dataAmerican Heart AssociationPH diagnosisClinical courseRespiratory deteriorationConsensus guidelinesInfant groupLung diseaseHeart AssociationComplex cardiovascular conditionsRisk factorsOxygen saturationInfantsFive-minute segmentsHeterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial
Gentle S, Rysavy M, Li L, Laughon M, Patel R, Jensen E, Hintz S, Ambalavanan N, Carlo W, Watterberg K, Laptook A, Keszler M, Vohr B, Hensman A, Vieira E, St. Pierre L, Burke R, Alksinis B, Caskey M, Hoffman L, Johnson K, Keszler M, Knoll A, Leach T, Little E, McGowan E, Stephens B, Watson V, Hibbs A, Walsh M, Wilson-Costello D, Newman N, Bhola M, Payne A, Siner B, Yalcinkaya G, Truog W, Kilbride H, Gauldin C, Pallotto E, Holmes A, Johnson K, Scott A, Poindexter B, Schibler K, Merhar S, Yolton K, Grisby C, Beiersdorfer T, Cahill T, Dudley J, Gratton T, Kirker K, Thompson J, Wuertz S, Polin R, Cotton M, Goldberg R, Malcolm W, Goldstein R, Finkle J, Ashley P, Fisher K, Gustafson K, Mago-Shah D, Warren M, Bose C, Bernhardt J, Bose G, Wereszczak J, Warner D, Clark C, Kicklighter S, Bentley A, Edwards L, Rhodes-Ryan G, White D, Carlton D, Stoll B, Hale E, Loggins Y, Bottcher D, Carter S, Kendrick-Allywood S, Mulligan LaRossa M, Mackie C, Smikle G, Comerford L, Laursen J, Sanders A, Maitre N, Adams-Chapman I, Bremer A, Wilson Archer S, Higgins R, Tyson J, Khan A, Kennedy K, Mosquera R, Duncan A, McDavid G, Alaniz N, Allain E, Arldt-McAlister J, Sana Boral D, Burson K, Dempsey A, Eason E, Evans P, Garcia C, Green C, Hall D, Jiminez M, John J, Jones P, Lillie M, Martin K, Martin S, Mason C, McKee S, Poe M, Rennie K, Rodgers S, Siddiki S, Sperry D, Stephens E, Pierce Tate P, Wright S, Sanchez P, Nelin L, Jadcherla S, Slaughter J, Luzader P, Burkhardt S, Carey H, Chao M, Clark E, Fearns E, Fortney C, Fowler A, Grothause J, Gutentag J, Hague C, McCool J, Nelin M, Park C, Pietruszewski L, Purnell J, Shadd J, Small K, Stein M, Sullivan M, Sullivan R, Timan C, Yeates K, Yoseff-Salameh L, Keim S, Newton J, Levengood K, Batterson N, Rice C, Moallem M, Harmon H, Das A, Wallace D, Banna C, Gantz M, O'Donnell Auman J, Crawford M, Gabrio J, Leblond D, Newman J, Petrie Huitema C, vonLehmden A, Zaterka-Baxter K, Li L, Van Meurs K, Stevenson D, Chock V, Ball M, Bentley B, Chitkara R, Davis A, DeAnda M, DeBattista A, Earhart B, Huffman L, Krueger C, Lucash R, Proud M, Hitchner Reichert E, Sivakumar D, Taylor H, Weiss H, Peralta-Carcelen M, Collins M, Cosby S, Biasini F, Domnanovich K, McNair T, Phillips V, Whitley S, York Chapman S, Devaskar U, Chanlaw T, Geller R, Garg M, Purdy I, Bell E, Colaizy T, Widness J, Brumbaugh J, Johnson K, Walker J, Goeke C, Schmelzel M, Eastman D, Baack M, Meyer L, Hogden L, Henning M, Elenkiwich C, Broadbent M, Van Muyden S, Ellsbury D, Campbell D, Tud T, Fuller J, Beauman S, Backstrom Lacy C, Ruffner Hanson M, Hartenberger C, Kuan E, Lowe S, Sokol G, Papile L, Harmon H, Hines A, Lytle C, Herron D, Gunn S, Smiley L, Dawn Wilson L, DeMauro S, Schmidt B, Eichenwald E, Kirpalani H, Abbasi S, Mancini T, Chaudhary A, Cucinotta D, Bernbaum J, Freeman Duncan A, Dysart K, Gerdes M, Hurt H, Snyder J, Ziolkowski K, D'Angio C, Guillet R, Myers G, Binion K, Chess P, Fallone C, Farooq O, Kent A, Maffett D, Merzbach J, Orme C, Sacilowski M, Sabaratnam P, Scorsone A, Wadkins H, Wynn K, Yost K, Reynolds A, Lakshminrusimha S, Chandrasekharan P, Guilford S, Hartley-McAndrews M, Williams A, Zorn W, Li E, Donato J, McKee K, Coleman K, Bean S, Coleman C, Horihan C, Wyckoff M, Brion L, Heyne R, Vasil D, Adams S, Chen L, De Leon M, Eubanks F, Guzman A, Heyne E, Lee L, Madden L, McDougald E, Pavageau L, Sepulveda P, Twell Boatman C, Tolentino-Plata K, Vera A, Waterbury J, Yoder B, Ohls R, Baserga M, Winter S, Minton S, Sheffield M, Rau C, Baker S, Burnett J, Christensen S, Cole Bledsoe L, Cunningham S, Davis B, Elmont J, Hall B, Loertscher M, Marchant T, Maxon E, McGrath K, Mickelsen H, Morshedzadeh G, Parry D, Reich B, Schaefer S, Stout K, Stuart A, Weaver-Lewis K, Woodbury K, Shankaran S, Chawla S, Natarajan G, Sood B, Bara R, Agarwal P, Bajaj M, Childs K, February M, Goldston L, Johnson M, Panaitescu B, Hinz Woldt E, Barks J, Carlson M, Christensen M, White D, Wiggins S. Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial. JAMA Network Open 2023, 6: e2315315. PMID: 37256621, PMCID: PMC10233424, DOI: 10.1001/jamanetworkopen.2023.15315.Peer-Reviewed Original ResearchConceptsSevere neurodevelopmental impairmentExtremely preterm infantsEffect of hydrocortisoneBronchopulmonary dysplasiaNeurodevelopmental impairmentNational Institute of Child HealthInstitute of Child HealthRandomized clinical trialsBaseline riskPreterm infantsGestational ageFollow-upQuartile 4Reduced rates of bronchopulmonary dysplasiaHuman Development Neonatal Research NetworkQuartile 1Clinical trialsMonths of corrected ageRate of bronchopulmonary dysplasiaRate of neurodevelopmental impairmentRisk of bronchopulmonary dysplasiaRelative riskDay of hydrocortisoneNeonatal Research NetworkTreatment groupsPatent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension.
Gentle S, Travers C, Clark M, Carlo W, Ambalavanan N. Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 921-928. PMID: 36378949, PMCID: PMC10111998, DOI: 10.1164/rccm.202203-0570oc.Peer-Reviewed Original ResearchConceptsBPD-associated pulmonary hypertensionPatent ductus arteriosusDuctus arteriosus patencyPreterm infantsBronchopulmonary dysplasiaPostnatal dayDuctus arteriosusPulmonary hypertensionRespiratory supportModerate to large patent ductus arteriosusBronchopulmonary dysplasia-associated pulmonary hypertensionPreterm infants of gestational ageInfants of gestational ageRetrospective case-control studyEvolving bronchopulmonary dysplasiaExtremely preterm infantsCase-control studyModifiable risk factorsGestational ageDuctal patencyComposite outcomeControl subjectsRisk factorsInfantsPatencyIntermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.
Gentle S, Travers C, Nakhmani A, Indic P, Carlo W, Ambalavanan N. Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 899-907. PMID: 36449386, PMCID: PMC10111996, DOI: 10.1164/rccm.202203-0580oc.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionIntermittent hypoxemiaHypoxemic eventsReceiver operating characteristicPreterm infantsPulmonary hypertensionControl subjectsWeeks 6 daysExtremely preterm infantsWeeks 0 daysHigher risk of deathIdentification of infantsCase-control studyRisk of deathBronchopulmonary dysplasiaDesaturation frequencyEchocardiographic dataPostnatal dayBedside biomarkersIH eventsHigh riskInfantsHypoxemiaHypertensionLong duration720 Improving survival without bronchopulmonary dysplasia in extremely preterm infants
Gentle S, Travers C, Winter L, Tucker J, Purvis D, Ambalavanan N, Carlo W. 720 Improving survival without bronchopulmonary dysplasia in extremely preterm infants. The American Journal Of The Medical Sciences 2023, 365: s395. DOI: 10.1016/s0002-9629(23)00727-9.Peer-Reviewed Original Research433 Achieved oxygen saturations and risk for bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. 433 Achieved oxygen saturations and risk for bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants. The American Journal Of The Medical Sciences 2023, 365: s231-s232. DOI: 10.1016/s0002-9629(23)00440-8.Peer-Reviewed Original Research462 Mid or standard frequency ventilation in infants with respiratory distress syndrome (MIDOS): a randomized clinical trial
Travers C, Dolma K, Gentle S, Shukla V, Armstead K, Ambalavanan N, Carlo W. 462 Mid or standard frequency ventilation in infants with respiratory distress syndrome (MIDOS): a randomized clinical trial. The American Journal Of The Medical Sciences 2023, 365: s248-s249. DOI: 10.1016/s0002-9629(23)00469-x.Peer-Reviewed Original Research467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants
Weaver L, Gentle S, Shukla V, Nakhmani A, Rahman F, Ambalavanan N, Askenazi D, Travers C. 467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants. The American Journal Of The Medical Sciences 2023, 365: s252. DOI: 10.1016/s0002-9629(23)00474-3.Peer-Reviewed Original Research600 Prediction of early oral feeding achievement in preterm infants
Shukla V, Gentle S, Cooley A, Singh A, Ambalavanan N, Carlo W, Salas A. 600 Prediction of early oral feeding achievement in preterm infants. The American Journal Of The Medical Sciences 2023, 365: s327-s328. DOI: 10.1016/s0002-9629(23)00608-0.Peer-Reviewed Original Research
2022
Delivery timing for the opioid–exposed infant
Sanusi A, Gray M, Xue Y, Mohr S, Curtis P, Dismukes J, Gentle S, Szychowski J, Brocato B, Casey B, Harper L, Sinkey R. Delivery timing for the opioid–exposed infant. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100719. PMID: 35977700, PMCID: PMC10961100, DOI: 10.1016/j.ajogmf.2022.100719.Peer-Reviewed Original ResearchConceptsNeonatal opioid withdrawal syndromeOpioid withdrawal syndromeOpioid-exposed infantsIncidence of neonatal opioid withdrawal syndromeNeonatal opioid withdrawal syndrome treatmentLate-term periodsEarly term deliveryOpioid-exposed neonatesWithdrawal syndromePrimary composite outcomeOpioid use disorderNeonatal outcomesTerm deliveryMedication-assisted treatmentSyndrome treatmentComposite outcomeRisk of neonatal opioid withdrawal syndromeSeverity of neonatal opioid withdrawal syndromeNeonatal intensive care unit admissionAmerican College of Obstetricians and GynecologistsPositive urine toxicology screenPrimary outcomeSecondary outcomesNeonatal intensive care unitPositive urine drug screenImproving birth certificate data accuracy in Alabama
Gentle S, Moore M, Blackmon R, Brugh B, Todd A, Wingate M, Mazzoni S. Improving birth certificate data accuracy in Alabama. Health Science Reports 2022, 5: e607. PMID: 35509413, PMCID: PMC9059177, DOI: 10.1002/hsr2.607.Peer-Reviewed Original ResearchCertification accuracyMultidisciplinary quality improvement effortsBirth certificate variablesBirth certificate dataPerinatal Quality CollaborativeStrategizing public health interventionsQuality improvement effortsMonitoring population healthVital statistics dataHealth care specialistsPublic health interventionsProportion of hospitalsPublic health surveillanceThirty-one hospitalsPopulation healthCertificate dataHealth interventionsCare specialistsBirth certificatesVital statisticsIdentified several factorsIndividual hospitalsHealth surveillanceImprovement effortsBirth data