Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants
Gentle S, Ahmed K, Yi N, Morrow C, Ambalavanan N, Lal C, Patel R. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biology 2020, 38: 101782. PMID: 33166868, PMCID: PMC7658701, DOI: 10.1016/j.redox.2020.101782.Peer-Reviewed Original ResearchConceptsWeeks post menstrual agePost menstrual ageBronchopulmonary dysplasiaPreterm infantsOral microbiomeBronchopulmonary dysplasia statusMorbidities of prematurityNO bioavailabilityBronchopulmonary dysplasia developmentNitric oxideAssociated with morbidityMenstrual ageNR activitySevere morbidityOral microbiotaPretermInfantsTherapeutic targetNitrate reductase activityPrematurityDysplasiaWeeksBioavailabilityNitrate reductaseDiseaseNeonatal comorbidities and gasotransmitters
Gentle S, Tipple T, Patel R. Neonatal comorbidities and gasotransmitters. Nitric Oxide 2020, 97: 27-32. PMID: 32014495, DOI: 10.1016/j.niox.2020.01.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon MonoxideGasotransmittersHumansHydrogen SulfideNitric OxideSignal TransductionConceptsRegulating various signaling pathwaysHypoxic ischemic encephalopathyFormation of secondary metabolitesTherapeutic attenuationNeonatal comorbiditiesNecrotizing enterocolitisPulmonary hypertensionIschemic encephalopathyNeonatal physiologyVasodilatory effectSecondary metabolitesSignaling pathwayGasotransmitter hydrogen sulfideConstitutive productionNitric oxideMolecule productionTherapeutic supplementAnti-microbialCellular deathInduce productionAnti-inflammatoryComorbiditiesEndogenous formationEnterocolitis