2021
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Neonatal comorbidities and gasotransmitters
Gentle S, Tipple T, Patel R. Neonatal comorbidities and gasotransmitters. Nitric Oxide 2020, 97: 27-32. PMID: 32014495, DOI: 10.1016/j.niox.2020.01.012.Peer-Reviewed Original ResearchConceptsRegulating various signaling pathwaysHypoxic ischemic encephalopathyFormation of secondary metabolitesTherapeutic attenuationNeonatal comorbiditiesNecrotizing enterocolitisPulmonary hypertensionIschemic encephalopathyNeonatal physiologyVasodilatory effectSecondary metabolitesSignaling pathwayGasotransmitter hydrogen sulfideConstitutive productionNitric oxideMolecule productionTherapeutic supplementAnti-microbialCellular deathInduce productionAnti-inflammatoryComorbiditiesEndogenous formationEnterocolitis