2021
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants
Gentle S, Ambalavanan N, Carlo W. Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants. Pediatric Research 2020, 88: 637-641. PMID: 31972856, PMCID: PMC7223394, DOI: 10.1038/s41390-020-0772-2.Peer-Reviewed Original ResearchConceptsPreterm infantsCPAP discontinuationOxygen saturationHigher oxygen saturationBackgroundContinuous positive airway pressureConclusionsIn preterm infantsPositive airway pressureCase-control studyWeeks gestationGestational ageAirway pressureControl infantsCPAP exposureBaseline characteristicsCPAPPostnatal weekClinical variablesPretermInfantsInclusion criteriaConsecutive daysGestationFiO2DaysWeaning
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchMeSH KeywordsCannulaContinuous Positive Airway PressureCross-Over StudiesEquipment DesignFemaleGestational AgeHumansHypoxiaInfant, NewbornInfant, PrematureMaleNoseOxygen Inhalation TherapyConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrials