2021
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants
Gentle S, Ahmed K, Yi N, Morrow C, Ambalavanan N, Lal C, Patel R. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biology 2020, 38: 101782. PMID: 33166868, PMCID: PMC7658701, DOI: 10.1016/j.redox.2020.101782.Peer-Reviewed Original ResearchMeSH KeywordsBronchopulmonary DysplasiaHumansInfantInfant, Extremely PrematureInfant, NewbornMicrobiotaMouthNitrate ReductasesNitric OxideProspective StudiesConceptsWeeks post menstrual agePost menstrual ageBronchopulmonary dysplasiaPreterm infantsOral microbiomeBronchopulmonary dysplasia statusMorbidities of prematurityNO bioavailabilityBronchopulmonary dysplasia developmentNitric oxideAssociated with morbidityMenstrual ageNR activitySevere morbidityOral microbiotaPretermInfantsTherapeutic targetNitrate reductase activityPrematurityDysplasiaWeeksBioavailabilityNitrate reductaseDiseaseAirway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle S, Freeman A, Patel R, Ambalavanan N, Lal C. Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia. Respiratory Research 2020, 21: 244. PMID: 32957939, PMCID: PMC7504869, DOI: 10.1186/s12931-020-01508-8.Peer-Reviewed Original ResearchMeSH KeywordsBronchopulmonary DysplasiaCohort StudiesFemaleHumansInfant, Extremely PrematureInfant, NewbornMaleNitritesProspective StudiesTracheaConceptsTracheal aspiratesPreterm infantsNitrite levelsLow birth infantsComplications of prematurityAirways of infantsProspective cohort studyPremature infantsVentilated infantsBirth infantsIncreased nitrite levelsPredictive biomarkersPostnatal dayLung diseaseCohort studyInfantsAirwayConclusionsIn conclusionGestationElevated nitrite levelsUniversity of AlabamaAspirationPretermResultsInfantsPrematurityAssociation of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children.
Gentle S, Carlo W, Tan S, Gargano M, Ambalavanan N, Chawla S, Bell E, Bann C, Hintz S, Heyne R, Tita A, Higgins R. Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children. Obstetrics And Gynecology 2020, 135: 1377-1386. PMID: 32459430, PMCID: PMC7278037, DOI: 10.1097/aog.0000000000003882.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesChild, PreschoolDatabases, FactualFemaleGestational AgeHumansInfantInfant MortalityInfant, Extremely PrematureInfant, NewbornLogistic ModelsMagnesium SulfateMaleNeurodevelopmental DisordersPregnancyPregnancy OutcomePrenatal CarePrenatal Exposure Delayed EffectsProspective StudiesUnited StatesConceptsSevere neurodevelopmental impairmentExposed to antenatal corticosteroidsExposure to antenatal corticosteroidsAntenatal corticosteroidsWeeks of gestationNeurodevelopmental impairmentMagnesium sulfateAssociation of antenatal corticosteroidsEunice Kennedy Shriver National Institute of Child HealthMagnesium sulfate therapyNational Institute of Child HealthInstitute of Child HealthAssociated with lower ratesExposure groupRate of deathPreterm childrenNeurodevelopmental outcomesLogistic regression modelsCorticosteroidsFollow-upPrimary outcomeSecondary outcomesTherapyGestationNetwork hospitalsOxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants
Gentle S, Ambalavanan N, Carlo W. Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants. Pediatric Research 2020, 88: 637-641. PMID: 31972856, PMCID: PMC7223394, DOI: 10.1038/s41390-020-0772-2.Peer-Reviewed Original ResearchConceptsPreterm infantsCPAP discontinuationOxygen saturationHigher oxygen saturationBackgroundContinuous positive airway pressureConclusionsIn preterm infantsPositive airway pressureCase-control studyWeeks gestationGestational ageAirway pressureControl infantsCPAP exposureBaseline characteristicsCPAPPostnatal weekClinical variablesPretermInfantsInclusion criteriaConsecutive daysGestationFiO2DaysWeaning