2024
Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants. Archives Of Disease In Childhood 2024, 109: 941-947. PMID: 38937062, PMCID: PMC11503043, DOI: 10.1136/archdischild-2024-327014.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionOxygen saturation indexSurvival statusPreterm infantsPulmonary hypertensionHigher FiOLt;29 weeks' gestationFraction of inspired oxygenWeeks postmenstrual ageSingle-centre studyNon-invasive predictorCase-control studyPostmenstrual ageWeeks gestationBronchopulmonary dysplasiaRespiratory supportNon-survivorsInfantsOxygen saturationPatient outcomesPretermSurvivalHypertensionWeeksPredictors
2022
Improving Time to Independent Oral Feeding to Expedite Hospital Discharge in Preterm Infants.
Gentle S, Meads C, Ganus S, Barnette E, Munkus K, Carlo W, Salas A. Improving Time to Independent Oral Feeding to Expedite Hospital Discharge in Preterm Infants. Pediatrics 2022, 149 PMID: 35229126, DOI: 10.1542/peds.2021-052023.Peer-Reviewed Original ResearchConceptsIndependent oral feedingOral feeding initiationWeeks PMAPreterm infantsOral feedingFeeding initiationWeeks gestationAchievement of independent oral feedingMedian gestational ageCue-based feedingPlan-Do-Study-Act cyclesExpediting hospital dischargeGestational agePlan-Do-Study-ActBirth weightPretermInfantsHospital dischargeOutcome measuresFeeding assessmentWeeksPMAGestationMultidisciplinary teamAgeA Quality Improvement Bundle to Improve Outcomes in Extremely Preterm Infants in the First Week.
Travers C, Gentle S, Freeman A, Nichols K, Shukla V, Purvis D, Dolma K, Winter L, Ambalavanan N, Carlo W, Lal C. A Quality Improvement Bundle to Improve Outcomes in Extremely Preterm Infants in the First Week. Pediatrics 2022, 149 PMID: 35088085, PMCID: PMC9677934, DOI: 10.1542/peds.2020-037341.Peer-Reviewed Original ResearchConceptsSevere intracranial hemorrhageExtremely preterm infantsPreterm infantsIntracranial hemorrhageRates of acute kidney injuryMedian birth weightSpontaneous intestinal perforationDelayed cord clampingAcute kidney injuryQuality improvement initiativesBaseline rateGestational ageWeeks gestationCord clampingIndomethacin prophylaxisCongenital anomaliesIntestinal perforationBirth weightKidney injuryPrimary outcomeQuality improvement bundleInfantsFirst-weekBirthWeeksDuration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death
Gentle S, Carper B, Laughon M, Jensen E, Williams A, Travers C, Ambalavanan N, Lal C, Carlo W. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. Journal Of Perinatology 2022, 42: 454-460. PMID: 35034096, PMCID: PMC9007818, DOI: 10.1038/s41372-021-01269-2.Peer-Reviewed Original ResearchConceptsNoninvasive respiratory supportDuration of noninvasive respiratory supportBronchopulmonary dysplasiaRespiratory supportAssociated with bronchopulmonary dysplasiaDevelopment of bronchopulmonary dysplasiaRetrospective study of infantsStudy of infantsPreterm infantsWeeks gestationPropensity score matchingNoninvasive supportMedian durationRetrospective studyPotential confoundersIllness severityScore matchingInfantsPropensity scoreGestationDysplasiaDeathDurationAssociationPreterm
2020
Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants
Gentle S, Ambalavanan N, Carlo W. Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants. Pediatric Research 2020, 88: 637-641. PMID: 31972856, PMCID: PMC7223394, DOI: 10.1038/s41390-020-0772-2.Peer-Reviewed Original ResearchConceptsPreterm infantsCPAP discontinuationOxygen saturationHigher oxygen saturationBackgroundContinuous positive airway pressureConclusionsIn preterm infantsPositive airway pressureCase-control studyWeeks gestationGestational ageAirway pressureControl infantsCPAP exposureBaseline characteristicsCPAPPostnatal weekClinical variablesPretermInfantsInclusion criteriaConsecutive daysGestationFiO2DaysWeaning
2019
Oxygen saturation histogram monitoring to reduce death or retinopathy of prematurity: a quality improvement initiative
Gentle S, El-Ferzli G, Winter L, Salas A, Philips III J. Oxygen saturation histogram monitoring to reduce death or retinopathy of prematurity: a quality improvement initiative. Journal Of Perinatology 2019, 40: 163-169. PMID: 31506527, DOI: 10.1038/s41372-019-0486-7.Peer-Reviewed Original ResearchConceptsSevere retinopathy of prematurityRetinopathy of prematuritySevere retinopathyWeeks gestationReduce deathsRate of deathPreterm infantsConclusionIn infantsPrematurityGestationOxygen saturationHospital dischargeInfantsOutcome measuresQuality improvement initiativesDeathChart auditWeeksCare providersPeriodic assessmentRetinopathyIncreasing timeImprovement initiatives