2021
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle S, Freeman A, Patel R, Ambalavanan N, Lal C. Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia. Respiratory Research 2020, 21: 244. PMID: 32957939, PMCID: PMC7504869, DOI: 10.1186/s12931-020-01508-8.Peer-Reviewed Original ResearchConceptsTracheal aspiratesPreterm infantsNitrite levelsLow birth infantsComplications of prematurityAirways of infantsProspective cohort studyPremature infantsVentilated infantsBirth infantsIncreased nitrite levelsPredictive biomarkersPostnatal dayLung diseaseCohort studyInfantsAirwayConclusionsIn conclusionGestationElevated nitrite levelsUniversity of AlabamaAspirationPretermResultsInfantsPrematurity