2024
Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants. Archives Of Disease In Childhood 2024, 109: 941-947. PMID: 38937062, PMCID: PMC11503043, DOI: 10.1136/archdischild-2024-327014.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionOxygen saturation indexSurvival statusPreterm infantsPulmonary hypertensionHigher FiOLt;29 weeks' gestationFraction of inspired oxygenWeeks postmenstrual ageSingle-centre studyNon-invasive predictorCase-control studyPostmenstrual ageWeeks gestationBronchopulmonary dysplasiaRespiratory supportNon-survivorsInfantsOxygen saturationPatient outcomesPretermSurvivalHypertensionWeeksPredictors
2023
Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis
Ramanand P, Indic P, Gentle S, Ambalavanan N. Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis. 2016 Computing In Cardiology Conference (CinC) 2023, 50: 1-4. DOI: 10.22489/cinc.2023.354.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionCardiorespiratory networkComplications of PHHeart ratePH groupMechanisms of disease progressionRespiratory rateDisease progressionPretermInfantsOxygen saturationCardiorespiratory morbidityHypertensionGroupMean delayDysplasiaComplicationsMorbidity433 Achieved oxygen saturations and risk for bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. 433 Achieved oxygen saturations and risk for bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants. The American Journal Of The Medical Sciences 2023, 365: s231-s232. DOI: 10.1016/s0002-9629(23)00440-8.Peer-Reviewed Original Research467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants
Weaver L, Gentle S, Shukla V, Nakhmani A, Rahman F, Ambalavanan N, Askenazi D, Travers C. 467 Early fluid status and prediction of severe intraventricular hemorrhage or death in extremely preterm infants. The American Journal Of The Medical Sciences 2023, 365: s252. DOI: 10.1016/s0002-9629(23)00474-3.Peer-Reviewed Original Research
2022
Improving Time to Independent Oral Feeding to Expedite Hospital Discharge in Preterm Infants.
Gentle S, Meads C, Ganus S, Barnette E, Munkus K, Carlo W, Salas A. Improving Time to Independent Oral Feeding to Expedite Hospital Discharge in Preterm Infants. Pediatrics 2022, 149 PMID: 35229126, DOI: 10.1542/peds.2021-052023.Peer-Reviewed Original ResearchConceptsIndependent oral feedingOral feeding initiationWeeks PMAPreterm infantsOral feedingFeeding initiationWeeks gestationAchievement of independent oral feedingMedian gestational ageCue-based feedingPlan-Do-Study-Act cyclesExpediting hospital dischargeGestational agePlan-Do-Study-ActBirth weightPretermInfantsHospital dischargeOutcome measuresFeeding assessmentWeeksPMAGestationMultidisciplinary teamAgeDuration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death
Gentle S, Carper B, Laughon M, Jensen E, Williams A, Travers C, Ambalavanan N, Lal C, Carlo W. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. Journal Of Perinatology 2022, 42: 454-460. PMID: 35034096, PMCID: PMC9007818, DOI: 10.1038/s41372-021-01269-2.Peer-Reviewed Original ResearchConceptsNoninvasive respiratory supportDuration of noninvasive respiratory supportBronchopulmonary dysplasiaRespiratory supportAssociated with bronchopulmonary dysplasiaDevelopment of bronchopulmonary dysplasiaRetrospective study of infantsStudy of infantsPreterm infantsWeeks gestationPropensity score matchingNoninvasive supportMedian durationRetrospective studyPotential confoundersIllness severityScore matchingInfantsPropensity scoreGestationDysplasiaDeathDurationAssociationPreterm
2020
Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants
Gentle S, Ahmed K, Yi N, Morrow C, Ambalavanan N, Lal C, Patel R. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biology 2020, 38: 101782. PMID: 33166868, PMCID: PMC7658701, DOI: 10.1016/j.redox.2020.101782.Peer-Reviewed Original ResearchConceptsWeeks post menstrual agePost menstrual ageBronchopulmonary dysplasiaPreterm infantsOral microbiomeBronchopulmonary dysplasia statusMorbidities of prematurityNO bioavailabilityBronchopulmonary dysplasia developmentNitric oxideAssociated with morbidityMenstrual ageNR activitySevere morbidityOral microbiotaPretermInfantsTherapeutic targetNitrate reductase activityPrematurityDysplasiaWeeksBioavailabilityNitrate reductaseDiseaseAirway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle S, Freeman A, Patel R, Ambalavanan N, Lal C. Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia. Respiratory Research 2020, 21: 244. PMID: 32957939, PMCID: PMC7504869, DOI: 10.1186/s12931-020-01508-8.Peer-Reviewed Original ResearchConceptsTracheal aspiratesPreterm infantsNitrite levelsLow birth infantsComplications of prematurityAirways of infantsProspective cohort studyPremature infantsVentilated infantsBirth infantsIncreased nitrite levelsPredictive biomarkersPostnatal dayLung diseaseCohort studyInfantsAirwayConclusionsIn conclusionGestationElevated nitrite levelsUniversity of AlabamaAspirationPretermResultsInfantsPrematurityOxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants
Gentle S, Ambalavanan N, Carlo W. Oxygen saturation histograms predict nasal continuous positive airway pressure-weaning success in preterm infants. Pediatric Research 2020, 88: 637-641. PMID: 31972856, PMCID: PMC7223394, DOI: 10.1038/s41390-020-0772-2.Peer-Reviewed Original ResearchConceptsPreterm infantsCPAP discontinuationOxygen saturationHigher oxygen saturationBackgroundContinuous positive airway pressureConclusionsIn preterm infantsPositive airway pressureCase-control studyWeeks gestationGestational ageAirway pressureControl infantsCPAP exposureBaseline characteristicsCPAPPostnatal weekClinical variablesPretermInfantsInclusion criteriaConsecutive daysGestationFiO2DaysWeaning
2019
Oxygen Therapy and Pulmonary Hypertension in Preterm Infants
Gentle S, Abman S, Ambalavanan N. Oxygen Therapy and Pulmonary Hypertension in Preterm Infants. Clinics In Perinatology 2019, 46: 611-619. PMID: 31345551, DOI: 10.1016/j.clp.2019.05.009.Peer-Reviewed Original ResearchConceptsOxygen saturation targetsPulmonary hypertensionPreterm infantsSaturation targetsOxygen therapyHigher oxygen saturation targetsDevelopment of pulmonary hypertensionOptimal oxygen saturation targetsGoal of oxygen therapyEvaluating infantsCo-morbiditiesPretermHypertensionInfantsTherapyTrialsOutcomesNeOProMPrematurityHypoxemiaHyperoxemia
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrialsCaffeine controversies
Gentle S, Travers C, Carlo W. Caffeine controversies. Current Opinion In Pediatrics 2018, 30: 177-181. PMID: 29346141, DOI: 10.1097/mop.0000000000000588.Peer-Reviewed Original ResearchConceptsApnea of prematurityBronchopulmonary dysplasiaPreterm infantsEvidence of bronchopulmonary dysplasiaCaffeine usePatent ductus arteriosusRate of motor impairmentCaffeine therapyRate of deathRandomized controlled trialsDuctus arteriosusNeurodevelopmental impairmentTherapy initiationNeonatal careCaffeine groupFollow-upTiming of initiationInfantsPretermCaffeineDoseMotor impairmentRisk reductionImpairmentApnea