2023
Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension.
Gentle S, Travers C, Clark M, Carlo W, Ambalavanan N. Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 921-928. PMID: 36378949, PMCID: PMC10111998, DOI: 10.1164/rccm.202203-0570oc.Peer-Reviewed Original ResearchConceptsBPD-associated pulmonary hypertensionPatent ductus arteriosusDuctus arteriosus patencyPreterm infantsBronchopulmonary dysplasiaPostnatal dayDuctus arteriosusPulmonary hypertensionRespiratory supportModerate to large patent ductus arteriosusBronchopulmonary dysplasia-associated pulmonary hypertensionPreterm infants of gestational ageInfants of gestational ageRetrospective case-control studyEvolving bronchopulmonary dysplasiaExtremely preterm infantsCase-control studyModifiable risk factorsGestational ageDuctal patencyComposite outcomeControl subjectsRisk factorsInfantsPatencyIntermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.
Gentle S, Travers C, Nakhmani A, Indic P, Carlo W, Ambalavanan N. Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 899-907. PMID: 36449386, PMCID: PMC10111996, DOI: 10.1164/rccm.202203-0580oc.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionIntermittent hypoxemiaHypoxemic eventsReceiver operating characteristicPreterm infantsPulmonary hypertensionControl subjectsWeeks 6 daysExtremely preterm infantsWeeks 0 daysHigher risk of deathIdentification of infantsCase-control studyRisk of deathBronchopulmonary dysplasiaDesaturation frequencyEchocardiographic dataPostnatal dayBedside biomarkersIH eventsHigh riskInfantsHypoxemiaHypertensionLong duration
2020
Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia
Gentle S, Freeman A, Patel R, Ambalavanan N, Lal C. Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia. Respiratory Research 2020, 21: 244. PMID: 32957939, PMCID: PMC7504869, DOI: 10.1186/s12931-020-01508-8.Peer-Reviewed Original ResearchConceptsTracheal aspiratesPreterm infantsNitrite levelsLow birth infantsComplications of prematurityAirways of infantsProspective cohort studyPremature infantsVentilated infantsBirth infantsIncreased nitrite levelsPredictive biomarkersPostnatal dayLung diseaseCohort studyInfantsAirwayConclusionsIn conclusionGestationElevated nitrite levelsUniversity of AlabamaAspirationPretermResultsInfantsPrematurity
2018
Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial
Travers C, Carlo W, Nakhmani A, Bhatia S, Gentle S, Amperayani V, Indic P, Aban I, Ambalavanan N. Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial. The Journal Of Pediatrics 2018, 200: 98-103. PMID: 29705116, PMCID: PMC6109600, DOI: 10.1016/j.jpeds.2018.03.010.Peer-Reviewed Original ResearchConceptsEpisodes of intermittent hypoxemiaPreterm infantsNasal cannulaIntermittent hypoxemiaSupplemental oxygenRandomized cross-over trialCross-over trialGestational agePostnatal dayBirth weightPretermHypoxemiaDecreased episodesInfantsOxygen saturationCannulaHoursPatient monitoringPatientsBirthWeeksTrials