Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants
Gentle S, Ahmed K, Yi N, Morrow C, Ambalavanan N, Lal C, Patel R. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biology 2020, 38: 101782. PMID: 33166868, PMCID: PMC7658701, DOI: 10.1016/j.redox.2020.101782.Peer-Reviewed Original ResearchConceptsWeeks post menstrual agePost menstrual ageBronchopulmonary dysplasiaPreterm infantsOral microbiomeBronchopulmonary dysplasia statusMorbidities of prematurityNO bioavailabilityBronchopulmonary dysplasia developmentNitric oxideAssociated with morbidityMenstrual ageNR activitySevere morbidityOral microbiotaPretermInfantsTherapeutic targetNitrate reductase activityPrematurityDysplasiaWeeksBioavailabilityNitrate reductaseDiseasePredicting BPD: Lessons Learned From the Airway Microbiome of Preterm Infants
Gentle S, Lal C. Predicting BPD: Lessons Learned From the Airway Microbiome of Preterm Infants. Frontiers In Pediatrics 2020, 7: 564. PMID: 32117822, PMCID: PMC7011099, DOI: 10.3389/fped.2019.00564.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsAirway microbiomeChronic lung disease of prematurityLung disease of prematurityDiagnosis of bronchopulmonary dysplasiaPrediction of bronchopulmonary dysplasiaMicrobiome-mediated therapeuticsDisease of prematurityBronchopulmonary dysplasia developmentChronic lung diseaseAirways of newbornsHost immune systemTime of birthSystems biology approachBPD developmentClinical phenotypeMultifactorial etiologyAirwayImmune systemBacterial diversityInfantsMicrobiome signaturesBiology approachLow biomass