2024
Improving Time to Goals of Care Discussions in Invasively Ventilated Preterm Infants.
Gentle S, Cohen C, Carlo W, Winter L, Hallman M. Improving Time to Goals of Care Discussions in Invasively Ventilated Preterm Infants. Pediatrics 2024, 154 PMID: 39359206, PMCID: PMC11524032, DOI: 10.1542/peds.2024-066585.Peer-Reviewed Original ResearchConceptsPostmenstrual ageBronchopulmonary dysplasiaPreterm infantsTracheostomy placementWeeks' PMA.Identifying preterm infantsWeeks postmenstrual ageBPD infantsTracheostomy dependenceInvasive ventilationGoC discussionsVentilatory requirementsTracheostomyVentilator liberationInfantsHospital dischargeMultidisciplinary conferenceQuality improvement initiativesWeeksChart analysisUniversity of AlabamaSMART aimStatistical process control chartsProcess control chartsControl chart analysisAchieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants. Archives Of Disease In Childhood 2024, 109: 941-947. PMID: 38937062, PMCID: PMC11503043, DOI: 10.1136/archdischild-2024-327014.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionOxygen saturation indexSurvival statusPreterm infantsPulmonary hypertensionHigher FiOLt;29 weeks' gestationFraction of inspired oxygenWeeks postmenstrual ageSingle-centre studyNon-invasive predictorCase-control studyPostmenstrual ageWeeks gestationBronchopulmonary dysplasiaRespiratory supportNon-survivorsInfantsOxygen saturationPatient outcomesPretermSurvivalHypertensionWeeksPredictors737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes?
Gentle S, Carlo W, Ambalavanan N. 737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes? The American Journal Of The Medical Sciences 2024, 367: s461-s462. DOI: 10.1016/s0002-9629(24)00787-0.Peer-Reviewed Original Research
2023
Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis
Ramanand P, Indic P, Gentle S, Ambalavanan N. Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis. 2016 Computing In Cardiology Conference (CinC) 2023, 50: 1-4. DOI: 10.22489/cinc.2023.354.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionCardiorespiratory networkComplications of PHHeart ratePH groupMechanisms of disease progressionRespiratory rateDisease progressionPretermInfantsOxygen saturationCardiorespiratory morbidityHypertensionGroupMean delayDysplasiaComplicationsMorbidityInformation based similarity analysis of oxygen saturation recordings to detect Pulmonary hypertension in preterm infants
Ramanand P, Indic P, Gentle S, Ambalavanan N. Information based similarity analysis of oxygen saturation recordings to detect Pulmonary hypertension in preterm infants. Biomedical Signal Processing And Control 2023, 86: 105358. PMID: 37692106, PMCID: PMC10487283, DOI: 10.1016/j.bspc.2023.105358.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPulmonary hypertensionPreterm infantsClinical course of infantsDetect pulmonary hypertensionCourse of infantsPrevalence of PHManagement of PHOxygen saturation recordingsAssociated with multiple morbiditiesRisk of mortalityOxygen saturation dataAmerican Heart AssociationPH diagnosisClinical courseRespiratory deteriorationConsensus guidelinesInfant groupLung diseaseHeart AssociationComplex cardiovascular conditionsRisk factorsOxygen saturationInfantsFive-minute segmentsHeterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial
Gentle S, Rysavy M, Li L, Laughon M, Patel R, Jensen E, Hintz S, Ambalavanan N, Carlo W, Watterberg K, Laptook A, Keszler M, Vohr B, Hensman A, Vieira E, St. Pierre L, Burke R, Alksinis B, Caskey M, Hoffman L, Johnson K, Keszler M, Knoll A, Leach T, Little E, McGowan E, Stephens B, Watson V, Hibbs A, Walsh M, Wilson-Costello D, Newman N, Bhola M, Payne A, Siner B, Yalcinkaya G, Truog W, Kilbride H, Gauldin C, Pallotto E, Holmes A, Johnson K, Scott A, Poindexter B, Schibler K, Merhar S, Yolton K, Grisby C, Beiersdorfer T, Cahill T, Dudley J, Gratton T, Kirker K, Thompson J, Wuertz S, Polin R, Cotton M, Goldberg R, Malcolm W, Goldstein R, Finkle J, Ashley P, Fisher K, Gustafson K, Mago-Shah D, Warren M, Bose C, Bernhardt J, Bose G, Wereszczak J, Warner D, Clark C, Kicklighter S, Bentley A, Edwards L, Rhodes-Ryan G, White D, Carlton D, Stoll B, Hale E, Loggins Y, Bottcher D, Carter S, Kendrick-Allywood S, Mulligan LaRossa M, Mackie C, Smikle G, Comerford L, Laursen J, Sanders A, Maitre N, Adams-Chapman I, Bremer A, Wilson Archer S, Higgins R, Tyson J, Khan A, Kennedy K, Mosquera R, Duncan A, McDavid G, Alaniz N, Allain E, Arldt-McAlister J, Sana Boral D, Burson K, Dempsey A, Eason E, Evans P, Garcia C, Green C, Hall D, Jiminez M, John J, Jones P, Lillie M, Martin K, Martin S, Mason C, McKee S, Poe M, Rennie K, Rodgers S, Siddiki S, Sperry D, Stephens E, Pierce Tate P, Wright S, Sanchez P, Nelin L, Jadcherla S, Slaughter J, Luzader P, Burkhardt S, Carey H, Chao M, Clark E, Fearns E, Fortney C, Fowler A, Grothause J, Gutentag J, Hague C, McCool J, Nelin M, Park C, Pietruszewski L, Purnell J, Shadd J, Small K, Stein M, Sullivan M, Sullivan R, Timan C, Yeates K, Yoseff-Salameh L, Keim S, Newton J, Levengood K, Batterson N, Rice C, Moallem M, Harmon H, Das A, Wallace D, Banna C, Gantz M, O'Donnell Auman J, Crawford M, Gabrio J, Leblond D, Newman J, Petrie Huitema C, vonLehmden A, Zaterka-Baxter K, Li L, Van Meurs K, Stevenson D, Chock V, Ball M, Bentley B, Chitkara R, Davis A, DeAnda M, DeBattista A, Earhart B, Huffman L, Krueger C, Lucash R, Proud M, Hitchner Reichert E, Sivakumar D, Taylor H, Weiss H, Peralta-Carcelen M, Collins M, Cosby S, Biasini F, Domnanovich K, McNair T, Phillips V, Whitley S, York Chapman S, Devaskar U, Chanlaw T, Geller R, Garg M, Purdy I, Bell E, Colaizy T, Widness J, Brumbaugh J, Johnson K, Walker J, Goeke C, Schmelzel M, Eastman D, Baack M, Meyer L, Hogden L, Henning M, Elenkiwich C, Broadbent M, Van Muyden S, Ellsbury D, Campbell D, Tud T, Fuller J, Beauman S, Backstrom Lacy C, Ruffner Hanson M, Hartenberger C, Kuan E, Lowe S, Sokol G, Papile L, Harmon H, Hines A, Lytle C, Herron D, Gunn S, Smiley L, Dawn Wilson L, DeMauro S, Schmidt B, Eichenwald E, Kirpalani H, Abbasi S, Mancini T, Chaudhary A, Cucinotta D, Bernbaum J, Freeman Duncan A, Dysart K, Gerdes M, Hurt H, Snyder J, Ziolkowski K, D'Angio C, Guillet R, Myers G, Binion K, Chess P, Fallone C, Farooq O, Kent A, Maffett D, Merzbach J, Orme C, Sacilowski M, Sabaratnam P, Scorsone A, Wadkins H, Wynn K, Yost K, Reynolds A, Lakshminrusimha S, Chandrasekharan P, Guilford S, Hartley-McAndrews M, Williams A, Zorn W, Li E, Donato J, McKee K, Coleman K, Bean S, Coleman C, Horihan C, Wyckoff M, Brion L, Heyne R, Vasil D, Adams S, Chen L, De Leon M, Eubanks F, Guzman A, Heyne E, Lee L, Madden L, McDougald E, Pavageau L, Sepulveda P, Twell Boatman C, Tolentino-Plata K, Vera A, Waterbury J, Yoder B, Ohls R, Baserga M, Winter S, Minton S, Sheffield M, Rau C, Baker S, Burnett J, Christensen S, Cole Bledsoe L, Cunningham S, Davis B, Elmont J, Hall B, Loertscher M, Marchant T, Maxon E, McGrath K, Mickelsen H, Morshedzadeh G, Parry D, Reich B, Schaefer S, Stout K, Stuart A, Weaver-Lewis K, Woodbury K, Shankaran S, Chawla S, Natarajan G, Sood B, Bara R, Agarwal P, Bajaj M, Childs K, February M, Goldston L, Johnson M, Panaitescu B, Hinz Woldt E, Barks J, Carlson M, Christensen M, White D, Wiggins S. Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial. JAMA Network Open 2023, 6: e2315315. PMID: 37256621, PMCID: PMC10233424, DOI: 10.1001/jamanetworkopen.2023.15315.Peer-Reviewed Original ResearchConceptsSevere neurodevelopmental impairmentExtremely preterm infantsEffect of hydrocortisoneBronchopulmonary dysplasiaNeurodevelopmental impairmentNational Institute of Child HealthInstitute of Child HealthRandomized clinical trialsBaseline riskPreterm infantsGestational ageFollow-upQuartile 4Reduced rates of bronchopulmonary dysplasiaHuman Development Neonatal Research NetworkQuartile 1Clinical trialsMonths of corrected ageRate of bronchopulmonary dysplasiaRate of neurodevelopmental impairmentRisk of bronchopulmonary dysplasiaRelative riskDay of hydrocortisoneNeonatal Research NetworkTreatment groupsPatent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension.
Gentle S, Travers C, Clark M, Carlo W, Ambalavanan N. Patent Ductus Arteriosus and Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 921-928. PMID: 36378949, PMCID: PMC10111998, DOI: 10.1164/rccm.202203-0570oc.Peer-Reviewed Original ResearchConceptsBPD-associated pulmonary hypertensionPatent ductus arteriosusDuctus arteriosus patencyPreterm infantsBronchopulmonary dysplasiaPostnatal dayDuctus arteriosusPulmonary hypertensionRespiratory supportModerate to large patent ductus arteriosusBronchopulmonary dysplasia-associated pulmonary hypertensionPreterm infants of gestational ageInfants of gestational ageRetrospective case-control studyEvolving bronchopulmonary dysplasiaExtremely preterm infantsCase-control studyModifiable risk factorsGestational ageDuctal patencyComposite outcomeControl subjectsRisk factorsInfantsPatencyIntermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants.
Gentle S, Travers C, Nakhmani A, Indic P, Carlo W, Ambalavanan N. Intermittent Hypoxemia and Bronchopulmonary Dysplasia with Pulmonary Hypertension in Preterm Infants. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 899-907. PMID: 36449386, PMCID: PMC10111996, DOI: 10.1164/rccm.202203-0580oc.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionIntermittent hypoxemiaHypoxemic eventsReceiver operating characteristicPreterm infantsPulmonary hypertensionControl subjectsWeeks 6 daysExtremely preterm infantsWeeks 0 daysHigher risk of deathIdentification of infantsCase-control studyRisk of deathBronchopulmonary dysplasiaDesaturation frequencyEchocardiographic dataPostnatal dayBedside biomarkersIH eventsHigh riskInfantsHypoxemiaHypertensionLong duration
2022
Correction: Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death
Gentle S, Carper B, Laughon M, Jensen E, Williams A, Travers C, Ambalavanan N, Lal C, Carlo W. Correction: Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. Journal Of Perinatology 2022, 42: 550-550. PMID: 35314760, DOI: 10.1038/s41372-022-01364-y.Peer-Reviewed Original ResearchDuration of noninvasive respiratory supportNoninvasive respiratory supportBronchopulmonary dysplasiaRespiratory supportDuration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death
Gentle S, Carper B, Laughon M, Jensen E, Williams A, Travers C, Ambalavanan N, Lal C, Carlo W. Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death. Journal Of Perinatology 2022, 42: 454-460. PMID: 35034096, PMCID: PMC9007818, DOI: 10.1038/s41372-021-01269-2.Peer-Reviewed Original ResearchConceptsNoninvasive respiratory supportDuration of noninvasive respiratory supportBronchopulmonary dysplasiaRespiratory supportAssociated with bronchopulmonary dysplasiaDevelopment of bronchopulmonary dysplasiaRetrospective study of infantsStudy of infantsPreterm infantsWeeks gestationPropensity score matchingNoninvasive supportMedian durationRetrospective studyPotential confoundersIllness severityScore matchingInfantsPropensity scoreGestationDysplasiaDeathDurationAssociationPreterm
2021
MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants
Gentle S, Ahmed K, Yi N, Morrow C, Ambalavanan N, Lal C, Patel R. Bronchopulmonary dysplasia is associated with reduced oral nitrate reductase activity in extremely preterm infants. Redox Biology 2020, 38: 101782. PMID: 33166868, PMCID: PMC7658701, DOI: 10.1016/j.redox.2020.101782.Peer-Reviewed Original ResearchConceptsWeeks post menstrual agePost menstrual ageBronchopulmonary dysplasiaPreterm infantsOral microbiomeBronchopulmonary dysplasia statusMorbidities of prematurityNO bioavailabilityBronchopulmonary dysplasia developmentNitric oxideAssociated with morbidityMenstrual ageNR activitySevere morbidityOral microbiotaPretermInfantsTherapeutic targetNitrate reductase activityPrematurityDysplasiaWeeksBioavailabilityNitrate reductaseDiseasePredicting BPD: Lessons Learned From the Airway Microbiome of Preterm Infants
Gentle S, Lal C. Predicting BPD: Lessons Learned From the Airway Microbiome of Preterm Infants. Frontiers In Pediatrics 2020, 7: 564. PMID: 32117822, PMCID: PMC7011099, DOI: 10.3389/fped.2019.00564.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsAirway microbiomeChronic lung disease of prematurityLung disease of prematurityDiagnosis of bronchopulmonary dysplasiaPrediction of bronchopulmonary dysplasiaMicrobiome-mediated therapeuticsDisease of prematurityBronchopulmonary dysplasia developmentChronic lung diseaseAirways of newbornsHost immune systemTime of birthSystems biology approachBPD developmentClinical phenotypeMultifactorial etiologyAirwayImmune systemBacterial diversityInfantsMicrobiome signaturesBiology approachLow biomass
2018
Caffeine controversies
Gentle S, Travers C, Carlo W. Caffeine controversies. Current Opinion In Pediatrics 2018, 30: 177-181. PMID: 29346141, DOI: 10.1097/mop.0000000000000588.Peer-Reviewed Original ResearchConceptsApnea of prematurityBronchopulmonary dysplasiaPreterm infantsEvidence of bronchopulmonary dysplasiaCaffeine usePatent ductus arteriosusRate of motor impairmentCaffeine therapyRate of deathRandomized controlled trialsDuctus arteriosusNeurodevelopmental impairmentTherapy initiationNeonatal careCaffeine groupFollow-upTiming of initiationInfantsPretermCaffeineDoseMotor impairmentRisk reductionImpairmentApnea