2012
Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice
Gross ER, Gershon MD, Margolis KG, Gertsberg ZV, Li Z, Cowles RA. Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice. Gastroenterology 2012, 143: 408-417.e2. PMID: 22609381, PMCID: PMC3687781, DOI: 10.1053/j.gastro.2012.05.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholine O-AcetyltransferaseCholinergic NeuronsEnterochromaffin CellsIntestinal MucosaKetanserinMaleMiceMice, Inbred C57BLMice, KnockoutMuscarinic AntagonistsReceptor, Serotonin, 5-HT2AScopolamineSelective Serotonin Reuptake InhibitorsSerotonergic NeuronsSerotoninSerotonin AntagonistsSerotonin Plasma Membrane Transport ProteinsTryptophan HydroxylaseConceptsSelective serotonin re-uptake inhibitorsSerotonin re-uptake inhibitorsRe-uptake inhibitorsWild-type miceIntestinal mucosaSerotonin re-uptake transporterCholinergic submucosal neuronsIntestinal mucosal epitheliumRe-uptake transporterTryptophan hydroxylase 1Tryptophan hydroxylase 2Submucosal neuronsCholinergic neuronsCholine acetyltransferaseNeuronal serotoninMucosal growthMucosal epitheliumMucosal cellsSERT knockoutEpithelial proliferationAbstractTextMiceHydroxylase 2MucosaNeural precursors
2001
Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide
Cowles R, Segura B, Mulholland M. Stimulation of rat pancreatic exocrine secretion by cocaine- and amphetamine-regulated transcript peptide. Peptides 2001, 99: 61-68. PMID: 11257316, DOI: 10.1016/s0167-0115(01)00226-9.Peer-Reviewed Original ResearchConceptsPancreatic exocrine secretionRat pancreatic exocrine secretionAmphetamine-regulated transcript peptideEffects of CARTPeptide-induced increaseCART peptideExocrine secretionAmylase secretionTranscript peptidePancreatic secretionPancreatic aciniPancreatic secretory functionCombination of atropinePeripheral nervous systemRat pancreatic aciniAnesthetized ratsPeripheral tissuesNervous systemSecretory functionStimulatory effectSecretionAcinar unitsFour-fold increaseAtropineAcetylcholine