2004
Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells
Segura BJ, Zhang W, Xiao L, Turner D, Cowles RA, Logsdon C, Mulholland MW. Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. Journal Of Surgical Research 2004, 116: 42-54. PMID: 14732348, DOI: 10.1016/s0022-4804(03)00281-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCalciumCalcium ChannelsCalcium SignalingCulture TechniquesDose-Response Relationship, DrugDrug Administration ScheduleEnzyme ActivationGuinea PigsImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLysophospholipidsMyenteric PlexusNeurogliaPertussis ToxinReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledRNA, MessengerSphingolipidsSphingosineType C PhospholipasesConceptsSignal transduction cascadeEnteric nervous systemEnteric gliaLipid lysophosphatidic acidMajor cell typesRT-PCR analysisTransduction cascadeGlial cellsNervous systemEDG-1Trisphosphate receptorCalcium signalingLysophosphatidic acidCell typesExtracellular receptorsPhospholipase CEdg-3Enteric glial cellsBioactive lipidsEdg-5S1P effectsSphingomyelin metabolitesDigestive activityImmunocytochemical analysisEnteric neurons
2000
ATP Induces c-fos Expression in C6 Glioma Cells by Activation of P2Y Receptors
Zhang W, Turner D, Segura B, Cowles R, Mulholland M. ATP Induces c-fos Expression in C6 Glioma Cells by Activation of P2Y Receptors. Journal Of Surgical Research 2000, 94: 49-55. PMID: 11038302, DOI: 10.1006/jsre.2000.5984.Peer-Reviewed Original ResearchConceptsProtein kinase CType II protein kinaseMAP kinase kinasePhosphorylated MAP kinaseType I proteinC6 glioma cellsSecond messenger pathwaysExtracellular ATP functionsC-fos mRNA expressionKinase kinaseProtein kinaseGlioma cellsMAP kinasePhospholipase C inhibitorCalmodulin kinaseI proteinKinase CKinaseATP functionsMessenger pathwaysC inhibitorMRNA expressionCellular proliferationMultifactorial regulationC-fos expression