2004
Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells
Segura BJ, Zhang W, Xiao L, Turner D, Cowles RA, Logsdon C, Mulholland MW. Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. Journal Of Surgical Research 2004, 116: 42-54. PMID: 14732348, DOI: 10.1016/s0022-4804(03)00281-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCalciumCalcium ChannelsCalcium SignalingCulture TechniquesDose-Response Relationship, DrugDrug Administration ScheduleEnzyme ActivationGuinea PigsImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLysophospholipidsMyenteric PlexusNeurogliaPertussis ToxinReceptors, Cytoplasmic and NuclearReceptors, G-Protein-CoupledRNA, MessengerSphingolipidsSphingosineType C PhospholipasesConceptsSignal transduction cascadeEnteric nervous systemEnteric gliaLipid lysophosphatidic acidMajor cell typesRT-PCR analysisTransduction cascadeGlial cellsNervous systemEDG-1Trisphosphate receptorCalcium signalingLysophosphatidic acidCell typesExtracellular receptorsPhospholipase CEdg-3Enteric glial cellsBioactive lipidsEdg-5S1P effectsSphingomyelin metabolitesDigestive activityImmunocytochemical analysisEnteric neurons
2001
Functional overlap of IP3- and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons
Turner D, Segura B, Cowles R, Zhang W, Mulholland M. Functional overlap of IP3- and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons. AJP Gastrointestinal And Liver Physiology 2001, 281: g208-g215. PMID: 11408274, DOI: 10.1152/ajpgi.2001.281.1.g208.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Diphosphate RiboseAdenosine TriphosphateAnesthetics, LocalAnimalsBiological TransportCaffeineCalciumCalcium Channel BlockersCinnarizineCyclic ADP-RiboseDantroleneGuinea PigsInositol 1,4,5-TrisphosphateMicroinjectionsMuscle Relaxants, CentralMyenteric PlexusNeuronsPhosphodiesterase InhibitorsProcaineRyanodineConceptsMyenteric neuronsReceptor subtypesGuinea pig myenteric neuronsDifferent receptor subtypesMobilization of intracellularSuperfusion techniqueCalcium storesRyR antagonistSubsequent perfusionATP exposureNeuronsRyanodine receptorCADP-riboseAntagonistIntracellular microinjectionPerfusionMicroM ATPSubtypesRyRsIntracellularReceptorsTrisphosphate receptorCinnarizineSpecific ligandsMicroinjection