2022
Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Pierce RW, Giuliano JS, Whitney JE, Ouellette Y. Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics 2022, 149: s97-s102. PMID: 34970676, PMCID: PMC9754809, DOI: 10.1542/peds.2021-052888o.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunction syndromeOrgan dysfunction syndromeEndothelial dysfunctionIll childrenDysfunction syndromeEndothelial functionPediatric multiple organ dysfunction syndromeVascular segmentsOrgan systemsStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferencePatient-centered outcomesNon-English language studiesCombination of biomarkersData extraction formStudies of adultsCritical illnessCase seriesPremature infantsFunctional statusEligible studiesBias assessmentLeukocyte recruitment
2017
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome
Pierce RW, Merola J, Lavik JP, Kluger MS, Huttner A, Khokha MK, Pober JS. A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome. Journal Of Experimental Medicine 2017, 214: 3497-3505. PMID: 29097442, PMCID: PMC5716031, DOI: 10.1084/jem.20162143.Peer-Reviewed Original ResearchConceptsTumor necrosis factorSystemic capillary leakDermal microvascular endothelial cellsMicrovascular endothelial cellsPatient-derived endothelial cellsEndothelial cellsCapillary leakNormal human dermal microvascular endothelial cellsSystemic capillary leak syndromeBarrier functionCapillary leak syndromeHuman dermal microvascular endothelial cellsTransendothelial electrical resistanceEC barrier functionNormal endothelial cellsLeak syndromeCritical illnessFatal casesNecrosis factorBarrier recoverySiRNA knockdownEC culturesRhoB activationGreater increaseJunctional proteinsEndothelial Cell Function and Dysfunction in Critically Ill Children
Pierce RW, Giuliano JS, Pober JS. Endothelial Cell Function and Dysfunction in Critically Ill Children. Pediatrics 2017, 140: e20170355. PMID: 28759412, PMCID: PMC9923607, DOI: 10.1542/peds.2017-0355.Peer-Reviewed Original ResearchConceptsEndothelial cellsCritical illnessIll childrenCritically Ill ChildrenImmune cell recruitmentBiology of ECsEndothelial cell functionBroad anatomic distributionEntire vascular systemPathologic responseAnatomic distributionClinical correlationMaintenance of homeostasisBlood flowCell recruitmentBlood fluiditySystemic homeostasisCell functionSegmental differencesEC functionVascular systemIllnessChildrenHomeostasisSpecific role