Featured Publications
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis
Barmada A, Klein J, Ramaswamy A, Brodsky N, Jaycox J, Sheikha H, Jones K, Habet V, Campbell M, Sumida T, Kontorovich A, Bogunovic D, Oliveira C, Steele J, Hall E, Pena-Hernandez M, Monteiro V, Lucas C, Ring A, Omer S, Iwasaki A, Yildirim I, Lucas C. Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis. Science Immunology 2023, 8: eadh3455-eadh3455. PMID: 37146127, PMCID: PMC10468758, DOI: 10.1126/sciimmunol.adh3455.Peer-Reviewed Original ResearchConceptsMRNA vaccinesSARS-CoV-2 mRNA vaccinesSARS-CoV-2 mRNA vaccinationC-reactive protein levelsB-type natriuretic peptidePeripheral blood mononuclear cellsCardiac tissue inflammationDeep immune profilingSerum soluble CD163Vaccine-associated myocarditisCohort of patientsBlood mononuclear cellsCytotoxic T cellsLate gadolinium enhancementHypersensitivity myocarditisElevated troponinMRNA vaccinationImaging abnormalitiesNK cellsImmune profilingKiller cellsMyeloid responseNatriuretic peptideHumoral mechanismsInflammatory cytokines
2007
STAT3 Mutations in the Hyper-IgE Syndrome
Holland S, DeLeo F, Elloumi H, Hsu A, Uzel G, Brodsky N, Freeman A, Demidowich A, Davis J, Turner M, Anderson V, Darnell D, Welch P, Kuhns D, Frucht D, Malech H, Gallin J, Kobayashi S, Whitney A, Voyich J, Musser J, Woellner C, Schäffer A, Puck J, Grimbacher B. STAT3 Mutations in the Hyper-IgE Syndrome. New England Journal Of Medicine 2007, 357: 1608-1619. PMID: 17881745, DOI: 10.1056/nejmoa073687.Peer-Reviewed Original ResearchConceptsSrc homology 2Hyper-IgE syndromeIn-frame deletionMononuclear cellsIncreased innate immune responseInterleukin-6Tumor necrosis factor-alpha levelsElevated serum IgE levelsLevels of monocyte chemoattractant protein-1Sporadic casesIn vitro culture of mononuclear cellsMonocyte chemoattractant protein-1Innate immune responseInterleukin-6 signalingSerum IgE levelsLevels of cytokinesDisorders of immunityCultures of mononuclear cellsDNA bindingProinflammatory gene transcriptionDiscrete mutationsChemoattractant protein-1Missense mutationsSTAT3 mutationsPresence of interleukin-6